Towards functional antibody-based vaccines to prevent pre-erythrocytic malaria infection
| Autor: | Stefan H. I. Kappe, D. Noah Sather, Brandon K. Sack |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Modern medicine Immunology Plasmodium 03 medical and health sciences 0302 clinical medicine Immune system Malaria Vaccines Drug Discovery medicine Antigenic variation Animals Humans 030212 general & internal medicine Pharmacology biology Malaria vaccine Genetic heterogeneity medicine.disease biology.organism_classification Virology Malaria Disease Models Animal 030104 developmental biology biology.protein Molecular Medicine Antibody |
| Zdroj: | Expert Review of Vaccines. 16:403-414 |
| ISSN: | 1744-8395 1476-0584 |
| DOI: | 10.1080/14760584.2017.1295853 |
| Popis: | An effective malaria vaccine would be considered a milestone of modern medicine, yet has so far eluded research and development efforts. This can be attributed to the extreme complexity of the malaria parasites, presenting with a multi-stage life cycle, high genome complexity and the parasite's sophisticated immune evasion measures, particularly antigenic variation during pathogenic blood stage infection. However, the pre-erythrocytic (PE) early infection forms of the parasite exhibit relatively invariant proteomes, and are attractive vaccine targets as they offer multiple points of immune system attack. Areas covered: We cover the current state of and roadblocks to the development of an effective, antibody-based PE vaccine, including current vaccine candidates, limited biological knowledge, genetic heterogeneity, parasite complexity, and suboptimal preclinical models as well as the power of early stage clinical models. Expert commentary: PE vaccines will need to elicit broad and durable immunity to prevent infection. This could be achievable if recent innovations in studying the parasites' infection biology, rational vaccine selection and design as well as adjuvant formulation are combined in a synergistic and multipronged approach. Improved preclinical assays as well as the iterative testing of vaccine candidates in controlled human malaria infection trials will further accelerate this effort. |
| Databáze: | OpenAIRE |
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