A Smart Multifunctional Nanoparticle for Enhanced Near-Infrared Image-Guided Photothermal Therapy Against Gastric Cancer

Autor: Hongbo Wei, Shengxue Hu, Xiaoming Zheng, Rongpu Liang, Dongbing Ding, Bo Wei, Jun Shao, Xudong Zhu
Rok vydání: 2021
Předmět:
Indocyanine Green
Photothermal Therapy
Polymers
Multifunctional nanoparticles
Biophysics
Pharmaceutical Science
Bioengineering
Multifunctional Nanoparticles
02 engineering and technology
010402 general chemistry
01 natural sciences
Biomaterials
chemistry.chemical_compound
International Journal of Nanomedicine
Stomach Neoplasms
In vivo
Cell Line
Tumor
Drug Discovery
medicine
Animals
Humans
Tumor growth
Original Research
Chitosan
Mice
Inbred BALB C
Chemistry
gastric cancer
nanoparticle
Organic Chemistry
Cancer
General Medicine
Phototherapy
Photothermal therapy
021001 nanoscience & nanotechnology
medicine.disease
Boronic Acids
Xenograft Model Antitumor Assays
In vitro
0104 chemical sciences
near-infrared imaging
Cancer cell
Cancer research
Female
Reactive Oxygen Species
Corrigendum
0210 nano-technology
Oligopeptides
Indocyanine green
Zdroj: International Journal of Nanomedicine
ISSN: 1178-2013
Popis: Jun Shao,1,* Rongpu Liang,1,* Dongbing Ding,1,* Xiaoming Zheng,1 Xudong Zhu,1 Shengxue Hu,2 Hongbo Wei,1 Bo Wei1 1Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, People’s Republic of China; 2College of Biological Science and Engineering, Fuzhou University, Fujian, 350108, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongbo Wei; Bo WeiDepartment of Gastrointestinal Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, People’s Republic of ChinaTel +86-20-85252228Email weihb@mail.sysu.edu.cn; weibo3@mail.sysu.edu.cnBackground: Surgery is considered to be a potentially curative approach for gastric cancer. However, most cases are diagnosed at a very advanced stage for the lack of typical symptoms in the initial stage, which makes it difficult to completely surgical resect of tumors. Early diagnosis and precise personalized intervention are urgent issues to be solved for improving the prognosis of gastric cancer. Herein, we developed an RGD-modified ROS-responsive multifunctional nanosystem for near-infrared (NIR) imaging and photothermal therapy (PTT) against gastric cancer.Methods: Firstly, the amphiphilic polymer was synthesized by bromination reaction and nucleophilic substitution reaction of carboxymethyl chitosan (CMCh) and 4-hydroxymethyl-pinacol phenylborate (BAPE). Then, it was used to encapsulate indocyanine green (ICG) and modified with RGD to form a smart multifunctional nanoparticle targeted to gastric cancer (CMCh-BAPE-RGD@ICG). The characteristics were determined, and the targeting capacity and biosafety were evaluated both in vitro and in vivo. Furthermore, CMCh-BAPE-RGD@ICG mediated photothermal therapy (PTT) effect was studied using gastric cancer cells (SGC7901) and SGC7901 tumor model.Results: The nanoparticle exhibited suitable size (≈ 120 nm), improved aqueous stability, ROS-responsive drug release, excellent photothermal conversion efficiency, enhanced cellular uptake, and targeting capacity to tumors. Remarkably, in vivo studies suggested that CMCh-BAPE-RGD@ICG could accurately illustrate the location and margin of the SGC7901 tumor through NIR imaging in comparison with non-targeted nanoparticles. Moreover, the antitumor activity of CMCh-BAPE-RGD@ICG-mediated PTT could effectively suppress tumor growth by inducing necrosis and apoptosis in cancer cells. Additionally, CMCh-BAPE-RGD@ICG demonstrated excellent biosafety both in vitro and in vivo.Conclusion: Overall, our study provides a biocompatible theranostic nanoparticle with enhanced tumor-targeting ability and accumulation to realize NIR image-guided PTT in gastric cancer.Keywords: gastric cancer, nanoparticle, indocyanine green, near-infrared imaging, photothermal therapy
Databáze: OpenAIRE
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