Can cocaine-induced neuroinflammation explain maladaptive cocaine-associated memories?
| Autor: | Mary C. Olmstead, Pascal Romieu, Katia Befort, Caroline Correia |
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| Přispěvatelé: | Department of Psychology, Queen's University [Kingston, Canada], Laboratoire de neurosciences cognitives et adaptatives (LNCA), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2019 |
| Předmět: |
Cognitive Neuroscience
media_common.quotation_subject [SDV]Life Sciences [q-bio] Drug availability Association 03 medical and health sciences Behavioral Neuroscience Cocaine-Related Disorders 0302 clinical medicine Cocaine Dopamine Uptake Inhibitors medicine Animals Humans Neuroinflammation ComputingMilieux_MISCELLANEOUS 030304 developmental biology media_common Memory Consolidation Inflammation 0303 health sciences Addiction Perspective (graphical) Brain medicine.disease Substance abuse Posttraumatic stress Neuropsychology and Physiological Psychology Intrusive memories Memory consolidation Cues Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience & Biobehavioral Reviews Neuroscience & Biobehavioral Reviews, Oxford: Elsevier Ltd., 2020, 111, pp.69-83. ⟨10.1016/j.neubiorev.2020.01.001⟩ |
| ISSN: | 1873-7528 |
| Popis: | Persistent and intrusive memories define a number of psychiatric disorders, including posttraumatic stress disorder and substance use disorder. In the latter, memory for drug-paired cues plays a critical role in sustaining compulsive drug use as these are potent triggers of relapse. As with many drugs, cocaine-cue associated memory is strengthened across presentations as cues become reliable predictors of drug availability. Recently, the targeting of cocaine-associated memory through disruption of the reconsolidation process has emerged as a potential therapeutic strategy; reconsolidation reflects the active process by which memory is re-stabilized after retrieval. In addition, a separate line of work reveals that neuroinflammatory markers, regulated by cocaine intake, play a role in memory processes. Our review brings these two literatures together by summarizing recent findings on cocaine-associated reconsolidation and cocaine-induced neuroinflammation. We discuss the interactions between reconsolidation processes and neuroinflammation following cocaine use, concluding with a new perspective on treatment to decrease risk of relapse to cocaine use. |
| Databáze: | OpenAIRE |
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