External validation of EORTC risk scores to predict recurrence after transurethral resection of brazilian patients with non-muscle invasive bladder cancer stages Ta and T1

Autor: Wilson F. S. Busato Jr., Carmen Australia Paredes Marcondes Ribas, Ottavio De Cobelli, Jurandir Marcondes Ribas-Filho, Gilberto L. Almeida
Rok vydání: 2016
Předmět:
Male
medicine.medical_specialty
Time Factors
Urology
Urinary Bladder
Population
030232 urology & nephrology
lcsh:RC870-923
Risk Assessment
Resection
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Risk Factors
Recurrence
Humans
Medicine
Neoplasm Invasiveness
Prospective Studies
education
Grading (tumors)
Aged
Neoplasm Staging
Aged
80 and over
education.field_of_study
Framingham Risk Score
Bladder cancer
business.industry
Carcinoma
Transurethral Resection of Prostate
External validation
Reproducibility of Results
Middle Aged
lcsh:Diseases of the genitourinary system. Urology
medicine.disease
Surgery
Urinary Bladder Neoplasms
030220 oncology & carcinogenesis
Concomitant
Disease Progression
Female
Original Article
Neoplasm Grading
Neoplasm Recurrence
Local
business
Non muscle invasive
Brazil
Zdroj: International braz j urol v.42 n.5 2016
International Braz J Urol
Sociedade Brasileira de Urologia (SBU)
instacron:SBU
International Brazilian Journal of Urology, Vol 42, Iss 5, Pp 932-941
International braz j urol, Volume: 42, Issue: 5, Pages: 932-941, Published: OCT 2016
International Brazilian Journal of Urology : official journal of the Brazilian Society of Urology
ISSN: 1677-5538
DOI: 10.1590/s1677-5538.ibju.2015.0169
Popis: Validate the EORTC risk tables in Brazilian patients with NMIBC. Methods: 205 patients were analyzed. The 6 parameters analyzed were: histologic grading, pathologic stage, size and number of tumors, previous recurrence rate and concomitant CIS. The time for first recurrence (TFR), risk score and probability of recurrence were calculated and compared to the probabilities obtained from EORTC risk tables. C-index was calculated and accuracy of EORTC tables was analyzed. Results: pTa was presented in 91 (44.4%) patients and pT1 in 114 (55.6%). Ninety-seven (47.3%) patients had solitary tumor, and 108 (52.7%) multiple tumors. One hundred and three (50.2%) patients had tumors smaller than 3 cm and 102 (40.8%) had bigger than 3 cm. Concomitant CIS was observed in 21 (10.2%) patients. Low grade was presented in 95 (46.3%) patients, and high grade in 110 (53.7%). Intravesical therapy was utilized in 105 (56.1%) patients. Recurrence was observed in 117 (57.1%) patients and the mean TFR was 14,2 ± 7,3 months. C-index was 0,72 for 1 year and 0,7 for 5 years. The recurrence risk was 28,8% in 1 year and 57,1% in 5 years, independently of the scoring risk. In our population, the EORTC risk tables overestimated the risk of recurrence in 1 year and underestimated in 5 years. Conclusion: The validation of the EORTC risk tables in Brazilian patients with NMIBC was satisfactory and should be stimulated to predict recurrence, although these may overestimated the risk of recurrence in 1 year and underestimated in 5 years.
Databáze: OpenAIRE
Externí odkaz: