Wnt3a promotes radioresistance via autophagy in squamous cell carcinoma of the head and neck
| Autor: | Qiancheng Jing, Diekuo Zhang, Donghai Huang, Yong Liu, Pingqing Tan, Huiling Ma, Jie Chen, Yuanzheng Qiu, Xiyu Chen, Lu Shanhong, Shuling Ren, Guo Li, Yuexiang Qin, Chao Liu, Hua Zheng, Shuiting Zhang |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine autophagy squamous cell carcinoma of the head and neck Mice Nude Electrons Radiation Tolerance 03 medical and health sciences 0302 clinical medicine In vivo Cell Line Tumor Wnt3A Protein Radioresistance medicine Animals Humans Wnt Signaling Pathway Proportional Hazards Models Squamous Cell Carcinoma of Head and Neck Chemistry Autophagy Wnt signaling pathway Cancer Wnt3a Original Articles Cell Biology Middle Aged medicine.disease Survival Analysis Hedgehog signaling pathway radioresistance stomatognathic diseases 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Molecular Medicine Original Article Beclin-1 Female prognosis WNT3A |
| Zdroj: | Journal of Cellular and Molecular Medicine |
| ISSN: | 1582-4934 1582-1838 |
| DOI: | 10.1111/jcmm.14394 |
| Popis: | The canonical Wnt/β‐catenin signalling pathway and autophagy play critical roles in cancer progression. However, the role of Wnt‐mediated autophagy in cancer radioresistance remains unclear. In this study, we found that irradiation activated the Wnt/β‐catenin and autophagic signalling pathways in squamous cell carcinoma of the head and neck (SCCHN). Wnt3a is a classical ligand that activated the Wnt/β‐catenin signalling pathway, induced autophagy and decreased the sensitivity of SCCHN to irradiation both in vitro and in vivo. Further mechanistic analysis revealed that Wnt3a promoted SCCHN radioresistance via protective autophagy. Finally, expression of the Wnt3a protein was elevated in both SCCHN tissues and patients' serum. Patients showing high expression of Wnt3a displayed a worse prognosis. Taken together, our study indicates that both the canonical Wnt and autophagic signalling pathways are valuable targets for sensitizing SCCHN to irradiation. |
| Databáze: | OpenAIRE |
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