Few serum proteins mediate APOE's association with dementia
| Autor: | Ram J. Bishnoi, Donald R. Royall, Raymond F. Palmer, Safa Al-Rubaye |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Apolipoprotein E Serum Proteins Physiology Intelligence lcsh:Medicine Social Sciences Biochemistry 0302 clinical medicine Endocrinology Immune Physiology Medicine and Health Sciences Psychology Ethnicities lcsh:Science Cognitive Impairment Innate Immune System Multidisciplinary Cognitive Neurology Blood Proteins Blood proteins Neurology Cytokines lipids (amino acids peptides and proteins) Research Article medicine.medical_specialty Mediation (statistics) Cognitive Neuroscience Immunology Apolipoproteins E 03 medical and health sciences Amphiregulin Internal medicine Growth Factors Mental Health and Psychiatry medicine Dementia Humans Allele Psychiatry Aged Adiponectin Endocrine Physiology business.industry Interleukins lcsh:R Cognitive Psychology Biology and Life Sciences Proteins Molecular Development medicine.disease 030104 developmental biology Immune System People and Places Cognitive Science lcsh:Q Population Groupings business 030217 neurology & neurosurgery Biomarkers Neuroscience Developmental Biology |
| Zdroj: | PLoS ONE PLoS ONE, Vol 12, Iss 3, p e0172268 (2017) |
| ISSN: | 1932-6203 |
| Popis: | The latent variable "δ" (for "dementia") appears to be uniquely responsible for the dementing aspects of cognitive impairment. Age, depression, gender and the apolipoprotein E (APOE) e4 allele are independently associated with δ. In this analysis, we explore serum proteins as potential mediators of APOE's specific association with δ in a large, ethnically diverse longitudinal cohort, the Texas Alzheimer's Research and Care Consortium (TARCC). APOE was associated only with C-Reactive Protein (CRP), Adiponectin (APN) and Amphiregulin (AREG), although the latter two's associations did not survive Bonferroni correction for multiple comparisons. All three proteins were associated with δ and had weak potential mediation effects on APOE's association with that construct. Our findings suggest that APOE's association with cognitive performance is specific to δ and partially mediated by serum inflammatory proteins. The majority of APOE's significant unadjusted effect on δ is unexplained. It may instead arise from direct central nervous system effects, possibly on native intelligence. If so, then APOE may exert a life-long influence over δ and therefore all-cause dementia risk. |
| Databáze: | OpenAIRE |
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