Electrochemotherapy as treatment option for hepatocellular carcinoma, a prospective pilot study
| Autor: | Ales Tomazic, Blaz Trotovsek, Gregor Sersa, Mihajlo Djokic, Damijan Miklavčič, Peter Popovič, Borut Štabuc, Maja Cemazar, Stojan Potrč, Bor Kos, Masa Bosnjak, Martina Niksic Zakelj, Rok Dezman |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Electrochemotherapy Carcinoma Hepatocellular Cirrhosis medicine.medical_treatment Pilot Projects Bleomycin Neoplasms Multiple Primary Lesion 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Humans Medicine Prospective Studies Adverse effect Aged Antibiotics Antineoplastic business.industry Liver Neoplasms General Medicine Perioperative Middle Aged medicine.disease Ablation Tumor Burden Treatment Outcome Oncology chemistry 030220 oncology & carcinogenesis Hepatocellular carcinoma Feasibility Studies Female 030211 gastroenterology & hepatology Surgery Radiology medicine.symptom business |
| Zdroj: | European Journal of Surgical Oncology. 44:651-657 |
| ISSN: | 0748-7983 |
| DOI: | 10.1016/j.ejso.2018.01.090 |
| Popis: | Background and objectives Electrochemotherapy provides non-thermal ablation of cutaneous as well as deep seated tumors. Based on positive results of the treatment of colorectal liver metastases, we conducted a prospective pilot study on hepatocellular carcinomas with the aim of testing the feasibility, safety and effectiveness of electrochemotherapy. Patients and methods Electrochemotherapy with bleomycin was performed on 17 hepatocellular carcinomas in 10 patients using a previously established protocol. The procedure was performed during open surgery and the patients were followed for median 20.5 months. Results Electrochemotherapy was feasible for all 17 lesions, and no treatment-related adverse events or major post-operative complications were observed. The median size of the treated lesions was 24 mm (range 8–41 mm), located either centrally, i.e., near the major hepatic vessels, or peripherally. The complete response rate at 3–6 months was 80% per patient and 88% per treated lesion. Conclusions Electrochemotherapy of hepatocellular carcinoma proved to be a feasible and safe treatment in all 10 patients included in this study. To evaluate the effectiveness of this method, longer observation period is needed; however the results at medium observation time of 20.5 months after treatment are encouraging, in 15 out of 17 lesions complete response was obtained. Electrochemotherapy is predominantly applicable in patients with impaired liver function due to liver cirrhosis and/or with lesions where a high-risk operation is needed to achieve curative intent, given the intra/perioperative risk for high morbidity and mortality. |
| Databáze: | OpenAIRE |
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