Late results of radium treatment of carcinoma of the cervix
| Autor: | Robert J Dickson |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
medicine.medical_specialty
Neoplasms Radiation-Induced medicine.medical_treatment Population Uterus Uterine Cervical Neoplasms Rectum Neoplasms Carcinoma Humans Medicine Radiology Nuclear Medicine and imaging education Cervix Aged Cervical cancer education.field_of_study Rectal Neoplasms business.industry Mortality rate General Medicine medicine.disease Surgery Radiation therapy medicine.anatomical_structure Urinary Bladder Neoplasms Uterine Neoplasms Carcinoma Squamous Cell Female Neoplasm Recurrence Local business Follow-Up Studies Radium |
| Zdroj: | Clinical Radiology. 23:528-535 |
| ISSN: | 0009-9260 |
| DOI: | 10.1016/s0009-9260(72)80036-9 |
| Popis: | Nine hundred and twenty-three out of 2423 patients with carcinoma of the cervix treated at the Marie Curie Hospital between September 1925 and December 31st, 1954 survived more than 5 years. All but 10 of these patients have been traced to the anniversary date of their treatment in 1969 or until earlier death. From an analysis of the death certificates of these patients when compared with the national death rates of the general population of the same age and sex, it was found that there was an excess number of deaths from carcinoma of the uterus and also from carcinoma of the bladder and rectum. The possible reasons for this excessive death rate are examined. The conclusion is reached that, although recurrence of carcinoma of the cervix does occur in years following the 5th anniversary, a number of those deaths from uterine carcinoma may be due to a second lesion induced by the radiotherapy. Similarly the excess number of deaths from carcinoma of the bladder and rectum appear to be related to the treatment of the cervical cancer. There is no evidence of a generalised effect of the radiation treatment, given almost entirely by radium alone in the first instance, in that no significant increase in the deaths from leukaemia was demonstrated and the number of deaths from intercurrent disease was almost identical with that expected in the normal population. A small number of patients died of the complications of treatment without evidence of recurrent carcinoma but it is postulated that at least some of these complications would have been avoided if more careful control of the placing of the radium had been available in the early years of this treatment. |
| Databáze: | OpenAIRE |
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