Enhanced T cell responsiveness to Mycobacterium bovis BCG r32-kDa Ag correlates with successful anti-tuberculosis treatment in humans
| Autor: | V. Hari Sai Priya, K. J. R. Murthy, G Suman Latha, Seyed E. Hasnain, Vijaya Lakshmi Valluri |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Tuberculosis
T-Lymphocytes T cell Immunology Enzyme-Linked Immunosorbent Assay Biochemistry Peripheral blood mononuclear cell Interferon-gamma Immune system Antigen medicine Humans Immunology and Allergy Interferon gamma Molecular Biology Antigens Bacterial Mycobacterium bovis biology Hematology biology.organism_classification medicine.disease medicine.anatomical_structure Case-Control Studies BCG Vaccine Bacterial antigen medicine.drug |
| Zdroj: | Cytokine. 52:190-193 |
| ISSN: | 1043-4666 |
| DOI: | 10.1016/j.cyto.2010.07.001 |
| Popis: | Th1 and Th2 cytokines play key role in protection from and pathogenesis of mycobacterial infection and their dynamic changes may predict clinical outcome of the patient. Patients with tuberculosis (TB) have a poorer cellular immune response to recombinant 32-kDa antigen (Ag) of Mycobacterium bovis (r32-kDa M. bovis) than do healthy volunteers. The basis for this observation was studied by evaluating the Th1 (gamma interferon [IFN-γ]) produced in response to the r32-kDa Ag M. bovis by peripheral blood mononuclear cells (PBMC) from patients with pulmonary TB (n=20), extra-pulmonary TB (n=13) and from healthy volunteers (n=9). Recombinant 32-kDa M. bovis stimulated PBMC from TB patients produced significantly lower levels of IFN-γ at 0 month, and increased at 2-4, and 6 months of treatment and were highly significant (p |
| Databáze: | OpenAIRE |
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