Identification of metabolites of selected benzophenanthridine alkaloids and their toxicity evaluation
| Autor: | Roman Sandor, Eva Táborská, Kristyna Noskova, Ondrej Pes, Adam Midlik, Kristyna Sebrlova, Jan Jurica, Gabriela Dovrtelova, Iva Slaninová |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Stereochemistry Clinical Biochemistry Pharmaceutical Science Hydroxylation 01 natural sciences Mass Spectrometry Analytical Chemistry 03 medical and health sciences chemistry.chemical_compound Alkaloids Biotransformation Liquid chromatography–mass spectrometry Drug Discovery Animals Sanguinarine Rats Wistar Spectroscopy Benzophenanthridines Chromatography 010401 analytical chemistry Isoquinolines Rats 0104 chemical sciences 3. Good health 030104 developmental biology Chelerythrine chemistry Toxicity Microsomes Liver Microsome Chromatography Liquid |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 121:174-180 |
| ISSN: | 0731-7085 |
| DOI: | 10.1016/j.jpba.2016.01.024 |
| Popis: | Selected benzo[c]phenathridine alkaloids were biotransformed using rat liver microsomes and identified by liquid chromatography and mass spectrometry. While the metabolites of commercially available sanguinarine and chelerythrine have been studied in detail, data about the metabolism of the minor alkaloids remained unknown. Reactions involved in transformation include single and/or double O-demethylation, demethylenation, reduction, and hydroxylation. Two metabolites, when isolated, purified and tested for toxicity, were found to be less toxic than the original compounds. |
| Databáze: | OpenAIRE |
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