The vasopressin and copeptin response to infection, severe sepsis, and septic shock*
| Autor: | Günter Luckner, Volker Wenzel, Nils G. Morgenthaler, Jakob Dörler, Walter R. Hasibeder, Hanno Ulmer, Stefan Jochberger, Viktoria D. Mayr, Martin W. Dünser |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Resuscitation Vasopressin medicine.medical_specialty Infections Critical Care and Intensive Care Medicine Severity of Illness Index Cohort Studies Sepsis Copeptin Intensive care Severity of illness medicine Humans Intensive care medicine Aged business.industry Septic shock Glycopeptides Middle Aged medicine.disease Shock Septic Arginine Vasopressin Intensive Care Units Anesthesia Shock (circulatory) Female medicine.symptom business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Critical Care Medicine. 37:476-482 |
| ISSN: | 0090-3493 |
| Popis: | To compare the course of arginine vasopressin (AVP) and copeptin plasma concentrations between patients with infection, severe sepsis, and septic shock.Prospective, closed-cohort study.Twelve-bed general and surgical intensive care unit and 33-bed internal medicine ward in a university hospital.Ten patients with infection, 22 with severe sepsis, and 28 with septic shock.None.Hemodynamic, laboratory and clinical data were recorded daily during the first 7 days after intensive care unit or hospital admission. Parallel thereto, blood was withdrawn to determine plasma AVP (radioimmunoassay) and copeptin (immunoluminometric assay) concentrations. Standard tests, a mixed effects model, and a linear regression analysis were used for statistical analysis. The AVP response was different between the three study groups (p0.001) but did not change over time (p = 0.12). Although patients with severe sepsis and septic shock had higher AVP levels than did patients with infection (both p0.001), no difference in AVP concentrations was seen between severe sepsis and septic shock patients (p = 0.98). No difference in AVP was observed between survivors and nonsurvivors at day 28 (p = 0.87). In patients with severe sepsis, serum osmolarity (p0.001), arterial pH (p = 0.001), lactate (p0.001), and Pao2 (p = 0.04) were associated with the course of AVP plasma levels, whereas it was serum osmolarity alone in patients with septic shock (p = 0.03). Plasma AVP concentrations correlated with copeptin (r = .614, p0.001), but this correlation was influenced by continuous veno-venous hemofiltration (p = 0.002).Severe sepsis induced a stronger AVP response than infection without systemic inflammation. However, the lack of a difference in AVP plasma concentrations between patients with and without shock indicates that the AVP system does not function normally in severe sepsis. Our data support the hypothesis that impaired AVP response is at least partially responsible for the failure to restore vascular tone in septic shock. |
| Databáze: | OpenAIRE |
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