Biomarkers associated with coronavirus disease-19 disease progression in a Mexican hospital
| Autor: | Francisco Moreno-Sanchez, Benigno E. Rodríguez-Soto, Raquel Gerson-Cwilich, Daniela Shveid-Gerson, Diana A. Villegas-Osorno, Alejandro Noguez-Ramos, Lorena López-Zepeda, Javier Garcia-Guerrero, Benjamín Valente-Acosta |
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| Rok vydání: | 2021 |
| Předmět: |
Medicine (General)
medicine.medical_specialty biology business.industry C-reactive protein Retrospective cohort study General Medicine Disease medicine.disease Procalcitonin Ferritin Pneumonia R5-920 Internal medicine Relative risk Cohort biology.protein Severe acute respiratory syndrome coronavirus 2. Coronavirus disease-19. Biomarkers. Lactic dehydrogenase. Ferritin. Mexico Medicine business |
| Zdroj: | Revista Médica del Hospital General de México, Vol 84, Iss 2 (2021) |
| ISSN: | 2524-177X |
| DOI: | 10.24875/hgmx.20000078 |
| Popis: | Introduction: The Coronavirus disease (COVID-19) pandemic is a worldwide challenge. There are few useful tools to predict patient outcomes. Identification of biomarkers able to predict progression of the disease could improve the treatment of these patients. Objective: The objective of the study was to identify biomarkers of disease progression among patients with severe COVID-19 pneumonia. Materials and methods: A retrospective cohort study was conducted among severe COVID-19 pneumonia patients hospitalized in the American British Cowdray Medical Center in Mexico City. Disease progression was defined as use of vasoactive amines, need of non-invasive or invasive mechanical ventilation or death. Studied biomarkers included neutrophil/lymphocyte index, lymphocyte/platelet Ratio, C reactive protein, procalcitonin, D Dimer, lactic dehydrogenase (LDH), ferritin, 25–OH–Vitamin D, and interleukin 6. Results: We report 46 patients with severe COVID-19 pneumonia. Mean age was 51 years, the majority of whom 30 (65%) male. Median hospitalization was 9 days. 23 (50%) of patients presented disease progression. Ferritin and LDH were strongly associated with disease progression among our cohort. In addition, age was associated with worst prognosis with a relative risk 4.5 (1.2-16.9, p = 0.003). Conclusions: Age, ferritin, and LDH were associated with disease progression among patients with severe COVID-19 pneumonia. |
| Databáze: | OpenAIRE |
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