The unconventional G-protein cycle of LRRK2 and Roco proteins
| Autor: | Arjan Kortholt, Laura M Nederveen-Schippers, Susanne Terheyden |
|---|---|
| Přispěvatelé: | Cell Biochemistry |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
G protein Mutant Context (language use) Neuronal toxicity Biology FAMILIAL PARKINSONS-DISEASE Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Guanosine Diphosphate Models Biological Biochemistry REPEAT KINASE 2 NEURONAL TOXICITY 03 medical and health sciences DOMAIN GTP-Binding Proteins REVEALS Guanine Nucleotide Exchange Factors Humans Phosphorylation Genetics Kinase Parkinson Disease LEUCINE-RICH-REPEAT-KINASE-2 LRRK2 HYDROLYSIS nervous system diseases 030104 developmental biology MUTANT Mutation Guanosine Triphosphate A kinase Guanine nucleotide exchange factor DISEASE-ASSOCIATED MUTATIONS GTP-BINDING |
| Zdroj: | Biochemical Society Transactions, 44(6), 1611-1616. PORTLAND PRESS LTD |
| ISSN: | 0300-5127 |
| Popis: | Mutations in the human leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of hereditary Parkinson's disease (PD). LRRK2 belongs to the Roco family of proteins, which are characterized by the presence of a Ras of complex proteins domain (Roc), a C-terminal of Roc domain (COR) and a kinase domain. Despite intensive research, much remains unknown about activity and the effect of PD-associated mutations. Recent biochemical and structural studies suggest that LRRK2 and Roco proteins are noncanonical G-proteins that do not depend on guanine nucleotide exchange factors or GTPase-activating proteins for activation. In this review, we will discuss the unusual G-protein cycle of LRRK2 in the context of the complex intramolecular LRRK2 activation mechanism. |
| Databáze: | OpenAIRE |
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