Biphasic effects of D3-receptor agonists, 7-OH-DPAT and PD128907, on the D1-receptor agonist-induced hyperactivity in mice
| Autor: | Tomohisa Mori, Kenshi Murase, Yasuyuki Ichimaru, Jiro Tanaka |
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| Rok vydání: | 1997 |
| Předmět: |
Agonist
Male medicine.medical_specialty Tetrahydronaphthalenes medicine.drug_class Motor Activity Partial agonist chemistry.chemical_compound Mice Dopamine receptor D1 Dopamine receptor D3 Dopamine Internal medicine Oxazines medicine Inverse agonist Animals Benzopyrans Drug Interactions Pharmacology 7-OH-DPAT Analysis of Variance Dose-Response Relationship Drug Chemistry Receptors Dopamine D2 Receptors Dopamine D1 Receptors Opioid kappa Receptors Dopamine D3 Benzazepines Endocrinology Dopamine Agonists Endogenous agonist medicine.drug |
| Zdroj: | Japanese journal of pharmacology. 73(3) |
| ISSN: | 0021-5198 |
| Popis: | Effects of D3-receptor agonists, 7-OH-DPAT and PD128907, on the D1-receptor agonist SKF81297-induced hyperactivity in mice were examined. 7-OH-DPAT and PD128907 significantly suppressed the SKF81297-induced hyperactivity at low doses, but significantly potentiated the hyperactivity at high doses. These D3-agonists alone had no effect on the motor activity. A kappa-receptor agonist that reduces dopamine release had no effect on the SKF81297-induced hyperactivity. These results suggest that lower doses of 7-OH-DPAT and PD128907 may negatively influence the D1-receptor mediated behaviors via post synaptic D3-receptors. On the other hand, higher doses of these compounds may positively influence these behaviors via D2- or D3-receptors. |
| Databáze: | OpenAIRE |
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