Prognostic Values of Matrix Metalloproteinase Family Expression in Human Colorectal Carcinoma
| Autor: | Shaoqiang Cheng, Jun-ichi Hamada, Norihiro Takemoto, Taro Kuramae, Tetsuya Moriuchi, Osamu Takahashi, Satoshi Kondo, Masaki Miyamoto, Toshimichi Asano, Mitsuhiro Tada, Motoki Abe |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Colorectal cancer Adenocarcinoma Matrix metalloproteinase GPI-Linked Proteins Kazal Motifs Disease-Free Survival Metastasis Extracellular matrix Matrix Metalloproteinase 10 Matrix Metalloproteinase 11 Predictive Value of Tests Humans Medicine RNA Messenger Aged Proportional Hazards Models Aged 80 and over Membrane Glycoproteins business.industry Liver Neoplasms Matrix Metalloproteinase 15 Cancer Tissue Inhibitor of Metalloproteinases Middle Aged Tissue inhibitor of metalloproteinase Prognosis medicine.disease Matrix Metalloproteinases Immunohistochemistry Female Surgery Matrix Metalloproteinase 1 Neoplasm Recurrence Local Colorectal Neoplasms business |
| Zdroj: | Journal of Surgical Research. 146:32-42 |
| ISSN: | 0022-4804 |
| DOI: | 10.1016/j.jss.2007.02.011 |
| Popis: | We examined expression patterns of matrix metalloproteinase (MMP), tissue inhibitor of metalloproteinase (TIMP), and reversion-inducing cysteine-rich protein with Kazal motifs (RECK) in colorectal cancer tissues to assess their prognostic significance.mRNA expressions of 17 MMPs, 4 TIMPs, and RECK were measured in 112 colorectal cancerous tissues, 20 normal mucosa tissues, and 11 metastatic liver lesions by real-time reverse-transcriptional-polymerase chain reaction. The protein level expressions were confirmed with immunohistochemistry.Cancers and normal mucosa displayed highly significant differences (P0.01) in expression of nine genes (MMP-1, -3, -7, -9, -10, -11, -12, -14, and RECK). Primary cancers and metastatic lesions showed highly significant differences (P0.01) in MMP-1, -10, -11, and TIMP-1. MMP-12 expression was higher in the primary tumors that were associated without hepatic metastasis than those with metastasis (P0.01). High expression of MMP-15 was related to longer disease-free survival (generalized Wilcoxon test, P0.0062; Cox hazard model, P0.028, hazard ratio, 0.099).MMP, TIMP, RECK expression patterns may provide an insight into extracellular matrix degrading (which is characteristic of colorectal cancers) and its role in metastasis. |
| Databáze: | OpenAIRE |
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