Sarcopenia is associated with increased mortality but not complications following resection and reconstruction of sarcoma of the extremities
| Autor: | Peter Nau, Nathan R. Hendrickson, Alan G. Shamrock, Kyle Kesler, Zachary Mayo, Natalie A. Glass, Benjamin J. Miller |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Sarcopenia medicine.medical_specialty Bone Neoplasms Soft Tissue Neoplasms Disease 030230 surgery Resection Tumor excision Young Adult 03 medical and health sciences Postoperative Complications 0302 clinical medicine Prevalence medicine Humans Neoplasm Metastasis Aged Retrospective Studies Aged 80 and over business.industry Hazard ratio Soft tissue Extremities Sarcoma General Medicine Middle Aged Plastic Surgery Procedures musculoskeletal system medicine.disease Iowa Surgery body regions Primary bone Oncology 030220 oncology & carcinogenesis Female business human activities |
| Zdroj: | Journal of Surgical Oncology. 121:1241-1248 |
| ISSN: | 1096-9098 0022-4790 |
| Popis: | Evidence regarding the impact of sarcopenia on operative outcomes in patients with sarcoma is lacking. We evaluated the relationship between sarcopenia and postoperative complications or mortality among patients undergoing tumor excision and reconstruction. METHODS: We retrospectively reviewed 145 patients treated with tumor excision and limb reconstruction for sarcoma of the extremities. Sarcopenia was defined as psoas index (PI) 5.45 cmThere were 101 soft tissue tumors and 44 primary bone tumors. Sarcopenia was present in 38 patients (26%). Sarcopenic patients were older (median age: 72 vs 59 years, P = .0010) and had larger tumors (86.5%,5 cm vs 77.7%, P = .023). Seventy-three patients experienced complications (51%) and 18 patients died within 1 year. Sarcopenia and metastatic disease were associated with increased 12-month mortality (hazard ratio [HR] = 6.68, P .001; HR: 8.51, P .001, respectively) but not complications (HR 1.45, P = .155, odds ratio, 1.32, P = .426, respectively).Sarcopenia and metastatic disease were independently associated with postoperative mortality but no complications following surgery. |
| Databáze: | OpenAIRE |
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