Metabolic enzymes dysregulation in heart failure: the prospective therapy
| Autor: | Priyanka Parihar, Mordhwaj S. Parihar |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Bioenergetics 030204 cardiovascular system & hematology Mitochondrion Health benefits Bioinformatics Mitochondria Heart 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine Flavonoids Heart Failure chemistry.chemical_classification business.industry Myocardium Effective management medicine.disease 030104 developmental biology Enzyme Endocrinology chemistry Metabolic regulation Metabolic enzymes Heart failure Dietary Supplements Energy Metabolism Cardiology and Cardiovascular Medicine business Oxidation-Reduction |
| Zdroj: | Heart Failure Reviews. 22:109-121 |
| ISSN: | 1573-7322 1382-4147 |
| DOI: | 10.1007/s10741-016-9588-x |
| Popis: | The heart failure accounts for the highest mortality rate all over the world. The development of preventive therapeutic approaches is still in their infancy. Owing to the extremely high energy demand of the heart, the bioenergetics pathways need to respond efficiently based on substrate availability. The metabolic regulation of such heart bioenergetics is mediated by various rate limiting enzymes involved in energy metabolism. Although all the pertinent mechanisms are not clearly understood, the progressive decline in the activity of metabolic enzymes leading to diminished ATP production is known to cause progression of the heart failure. Therefore, metabolic therapy that can maintain the appropriate activities of metabolic enzymes can be a promising approach for the prevention and treatment of the heart failure. The flavonoids that constitute various human dietary ingredients also effectively offer a variety of health benefits. The flavonoids target a variety of metabolic enzymes and facilitate effective management of the equilibrium between production and utilization of energy in the heart. This review discusses the broad impact of metabolic enzymes in the heart functions and explains how the dysregulated enzyme activity causes the heart failure. In addition, the prospects of targeting dysregulated metabolic enzymes by developing flavonoid-based metabolic approaches are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink