Possibility of Using Mesenchymal Stromal Cells to Restore Lymph Flow in Experimental Phlebothrombosis
| Autor: | Yu. V. Seryapina, S. V. Moshak, N V Onoprienko, G. A. Chastikin, V. A. Matveeva, I. V. Maiborodin, A. A. Anikeev, V. V. Morozov |
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| Rok vydání: | 2014 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Femoral vein Neovascularization Physiologic Bone Marrow Cells Mesenchymal Stem Cell Transplantation General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Lymph node stromal cell Medicine Animals Lymph sacs Lymphangiogenesis Lymphatic Vessels Venous Thrombosis business.industry Great saphenous vein Mesenchymal stem cell Mesenchymal Stem Cells General Medicine Anatomy Rats 030104 developmental biology Lymphatic system 030220 oncology & carcinogenesis cardiovascular system Lymph Lymph Nodes business |
| Zdroj: | Bulletin of experimental biology and medicine. 160(4) |
| ISSN: | 1573-8221 |
| Popis: | The possibility of formation of lymphatic vessels after introduction of autologous bone marrow-derived multipotent mesenchymal stromal cells transfected with GFP gene into thrombosed femoral vein was studied by fluorescent microscopy. Vascular thrombosis caused by ligation of the great vein with subsequent injection of thrombin solution was accompanied by blockade of regional lymph flow. The cells injected into thrombosed vein directly participate in the formation of new lymphatic vessels in the paravasal tissue surrounding the vein, its tissue region, and around regional lymph nodes. This is seen from bright specific fluorescence of individual cells in the walls of lymphatic vessels and all vascular layers and valves in UV light. |
| Databáze: | OpenAIRE |
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