'Programmed Polymeric Devices' for Pulsed Drug Delivery
Autor: | Stefaan C. De Smedt, Joseph Demeester, Barbara Stubbe |
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Rok vydání: | 2004 |
Předmět: |
Drug
Polymers media_common.quotation_subject Pharmaceutical Science Pharmacology Dosage form Drug Delivery Systems Osmotic Pressure Drug tolerance Medicine Pharmacology (medical) Pharmaceutical sciences media_common Drug Implants business.industry Hydrolysis Organic Chemistry Controlled release Enzymes Targeted drug delivery Drug delivery Plasma concentration Molecular Medicine business Biotechnology |
Zdroj: | Pharmaceutical Research. 21:1732-1740 |
ISSN: | 0724-8741 |
Popis: | Pharmaceutical research strives to design drug delivery systems that respond to therapeutic needs. Considering the facts that physiologic parameters (e.g., heart rate, blood pressure, and plasma concentration of hormones, plasma proteins, and enzymes) display constancy over time, drug delivery systems with a constant release profile have been designed. However, because of circadian rhythms in physiologic parameters and pathologic conditions (e.g., asthma, angina pectoris), the conventional paradigm concerning drug concentrations "the flatter the better" may not be what the organism may need. Instead, to correlate with our biological needs, "precisely timed drug delivery," which could be accomplished with "programmable dosage forms," is required. Precisely timed drug delivery may maximize therapeutic efficacy, may minimize dose frequency, and may reduce toxicity by avoiding side effects and drug tolerance. This paper outlines the concepts that have been proposed to release drugs in a pulsed manner from pharmaceutical devices. |
Databáze: | OpenAIRE |
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