Age-associated changes in mitogen-induced lymphoproliferation and lymphokine production in the long-lived brown-norway rat: effect of caloric restriction
| Autor: | Donna M. Murasko, I.Michael Goonewardene |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Senescence
Aging medicine.medical_specialty Lymphocyte chemical and pharmacologic phenomena Biology Immune system Interferon Rats Inbred BN Internal medicine Concanavalin A medicine Animals Lymphokines Cell growth Lymphokine Rats Endocrinology medicine.anatomical_structure Mitogen-activated protein kinase biology.protein Interferons Energy Intake Developmental Biology medicine.drug |
| Zdroj: | Mechanisms of Ageing and Development. 83:103-116 |
| ISSN: | 0047-6374 |
| DOI: | 10.1016/0047-6374(95)01609-4 |
| Popis: | We have previously demonstrated that age-related declines in Concanavalin A (ConA), induced proliferation and lymphokine production, occur in ad-libitum fed Brown Norway (AL BN) rats. Since caloric restriction (CR) extends lifespan, we expected that the age related changes in immune parameters would be delayed by CR. CR does act to delay age-related changes in proliferation in response to ConA. In addition, CR postpones the plateau in ConA induced interferon (IFN) production seen after 23 months of age in AL rats. However, CR does not postpone the age-related decline in ConA induced interleukin-2 (IL-2) production. Therefore, ConA induced IFN production maybe a good candidate as an early marker of physiologic aging, while ConA induced proliferative response is a possible candidate for a marker of late stages of aging. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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