Microcirculatory, Endothelial, and Inflammatory Responses in Critically Ill Patients With COVID-19 Are Distinct From Those Seen in Septic Shock: A Case Control Study
| Autor: | James Watchorn, Mark J. W. McPhail, Salma F Mujib, Philip Hopkins, Salvatore Napoli, Sam Hutchings, Francesca M. Trovato |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Endothelium Coronavirus disease 2019 (COVID-19) Critical Illness medicine.medical_treatment Inflammation Critical Care and Intensive Care Medicine Gastroenterology Pathogenesis Internal medicine Humans Medicine Prospective Studies Pathological Aged Interleukin-6 SARS-CoV-2 business.industry Critically ill Septic shock Microcirculation Case-control study COVID-19 Middle Aged medicine.disease Shock Septic medicine.anatomical_structure Cytokine Shock (circulatory) Emergency Medicine Female Endothelium Vascular Syndecan-1 medicine.symptom business Perfusion |
| Zdroj: | Shock |
| ISSN: | 1540-0514 1073-2322 |
| DOI: | 10.1097/shk.0000000000001672 |
| Popis: | Background: Critically ill patients with COVID-19 infection frequently exhibit a hyperinflammatory response and develop organ failures, however the underlying mechanisms are unclear. We investigated the microcirculatory, endothelial and inflammatory responses in critically ill COVID-19 patients and compared them to a group of patients with septic shock. Methods: Prospective observational case control study. 30 patients with COVID-19 admitted to the ICUs of a tertiary hospital were compared to 33 patients with septic shock. Measurements of sublingual microcirculatory flow were performed using Incident Dark Field (IDF) video-microscopy and serial measurements of IL-6 and Syndecan-1 levels were made. Findings: COVID-19 patients had significantly less vasoactive drug requirement and lower plasma lactate than those with septic shock. Microcirculatory flow was significantly worse in septic patients than those with COVID-19 (MFI 2.6 v 2.9 p 0.02, PPV 88 v 97% p |
| Databáze: | OpenAIRE |
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