Primary Nonfunction of Renal Allograft Secondary to Acute Oxalate Nephropathy
| Autor: | Ping L. Zhang, Leslie L. Rocher, Alan J. Koffron, Francis Dumler, Krishna Pothugunta, G. H. Reddy, Steven Cohn, Ravi Parasuraman, D. Samarapungavan, Vandad Raofi |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry lcsh:Surgery Calcium oxalate Urology Case Report lcsh:RD1-811 medicine.disease Oxalate Surgery Transplantation chemistry.chemical_compound chemistry Management of Technology and Innovation Biopsy medicine Polycystic kidney disease Oxalate nephropathy Differential diagnosis business Acute tubular necrosis |
| Zdroj: | Case Reports in Transplantation, Vol 2011 (2011) Case Reports in Transplantation |
| ISSN: | 2090-6951 2090-6943 |
| Popis: | Primary nonfunction (PNF) accounts for 0.6 to 8% of renal allograft failure, and the focus on causes of PNF has changed from rejection to other causes. Calcium oxalate (CaOx) deposition is common in early allograft biopsies, and it contributes in moderate intensity to higher incidence of acute tubular necrosis and poor graft survival. A-49-year old male with ESRD secondary to polycystic kidney disease underwent extended criteria donor kidney transplantation. Posttransplant, patient developed delayed graft function (DGF), and the biopsy showed moderately intense CaOx deposition that persisted on subsequent biopsies for 16 weeks, eventually resulting in PNF. The serum oxalate level was 3 times more than normal at 85 μmol/L (normal μmol/L). Allograft nephrectomy showed massive aggregates of CaOx crystal deposition in renal collecting system. In conclusion, acute oxalate nephropathy should be considered in the differential diagnosis of DGF since optimal management could change the outcome of the allograft. |
| Databáze: | OpenAIRE |
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