Stereoselective Cyclopropanation in the Synthesis of 3′-Deoxy-3′-C-hydroxymethyl-2′,3′-methylene-uridine
Autor: | Montserrat Shelbourne, Benjamin Alexander Mayes, Alistair Stewart, Alexander Yurek-George, Alexander C. Weymouth-Wilson, Laura Wallis, Andrew J. Tyrrell, Zofia Komsta, Adel Moussa |
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Rok vydání: | 2014 |
Předmět: | |
Zdroj: | Organic Letters. 16:4878-4880 |
ISSN: | 1523-7052 1523-7060 |
DOI: | 10.1021/ol502383c |
Popis: | The synthesis of the novel 2',3'-cyclopropane nucleoside 3'-deoxy-3'-C-hydroxymethyl-2',3'-methylene-uridine is described. Stereoselective construction of the cyclopropane ring was achieved via Simmons-Smith cyclopropanation of a benzyl protected silyl enol ether, which was itself derived from 1,2-O-isopropylidene-α-D-xylofuranose. |
Databáze: | OpenAIRE |
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