The Framingham Risk Score Is Associated with Chronic Graft Failure in Renal Transplant Recipients
| Autor: | Uwe J. F. Tietge, Stephan J. L. Bakker, Hannah L. M. Steffen, Daan Kremer, Josephine L. C. Anderson, Margot L. Poot |
|---|---|
| Přispěvatelé: | Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), Center for Liver, Digestive and Metabolic Diseases (CLDM) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Longitudinal study kidney dyslipidaemia KIDNEY-TRANSPLANTATION 030232 urology & nephrology 030204 cardiovascular system & hematology ACUTE REJECTION Article DISEASE 03 medical and health sciences 0302 clinical medicine Internal medicine medicine chronic graft failure Kidney OUTCOMES Framingham Risk Score Receiver operating characteristic Proportional hazards model business.industry Confounding General Medicine Transplantation medicine.anatomical_structure surgical procedures operative Renal transplant Cardiology Medicine Framingham risk score business transplantation |
| Zdroj: | Journal of Clinical Medicine, Vol 10, Iss 3287, p 3287 (2021) Journal of Clinical Medicine Volume 10 Issue 15 Journal of Clinical Medicine, 10(15):3287. MDPI AG |
| ISSN: | 2077-0383 |
| Popis: | Predicting chronic graft failure in renal transplant recipients (RTR) is an unmet clinical need. Chronic graft failure is often accompanied by transplant vasculopathy, the formation of de novo atherosclerosis in the transplanted kidney. Therefore, we determined whether the 10-year Framingham risk score (FRS), an established atherosclerotic cardiovascular disease prediction module, is associated with chronic graft failure in RTR. In this prospective longitudinal study, 600 well-characterised RTR were followed for 10 years. The association with death-censored chronic graft failure (n = 81, 13.5%) was computed. An extended Cox model showed that each one percent increase of the FRS significantly increased the risk of chronic graft failure by 4% (HR: 1.04, p < 0.001). This association remained significant after adjustment for potential confounders, including eGFR (HR: 1.03, p = 0.014). Adding the FRS to eGFR resulted in a higher AUC in a receiver operating curve (AUC = 0.79, p < 0.001) than eGFR alone (AUC = 0.75, p < 0.001), and an improvement in the model likelihood ratio statistic (67.60 to 88.39, p < 0.001). These results suggest that a combination of the FRS and eGFR improves risk prediction. The easy to determine and widely available FRS has clinical potential to predict chronic graft failure in RTR. |
| Databáze: | OpenAIRE |
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