Cortical norepinephrine release elicited in situ by N-methyl-d-aspartate (NMDA) receptor stimulation: a microdialysis study
| Autor: | John C. Lehmann, Rita J. Valentino, Véronique Robine |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Microdialysis N-Methylaspartate Time Factors Aconitine Stimulation Receptors N-Methyl-D-Aspartate Norepinephrine (medication) Norepinephrine chemistry.chemical_compound Internal medicine medicine Animals Rats Wistar Molecular Biology Chromatography High Pressure Liquid Cerebral Cortex General Neuroscience Glutamate receptor Rats Dizocilpine Kinetics Endocrinology chemistry Catecholamine NMDA receptor Neurology (clinical) Dizocilpine Maleate Dialysis Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 599:171-174 |
| ISSN: | 0006-8993 |
| Popis: | Norepinephrine (NE) release measured by microdialysis from probes positioned in the prefrontal cortex of anesthetized rats was increased when N-methyl-D-aspartate (NMDA) was contained in the microdialysis medium. NE release increased by a factor of 3.6 compared to prior baseline levels when 1 mM NMDA was applied for 30 min. This increase was largely reversible, and when a second stimulation was applied using aconitine (0.3 mM, 30 min), which acts on voltage-sensitive sodium channels, a second evoked release of NE was observed, of a similar magnitude as that evoked by NMDA. Dizocilpine (300 nM), which blocks cation channels associated with NMDA receptors, prevented the NMDA-elicited NE increase but not the aconitine-elicited increase. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|