Endogenous versus exogenous glucocorticoid responses to experimental bacterial sepsis
| Autor: | Richard Silverstein, Donald C. Johnson |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.drug_class
Immunology Antibiotics Bacteremia Receptors Cell Surface Endogeny Biology medicine.disease_cause Sepsis Mice medicine Animals Drosophila Proteins Immunology and Allergy Receptor Glucocorticoids Escherichia coli Infections Mice Inbred C3H Toll-like receptor Membrane Glycoproteins Toll-Like Receptors Cell Biology Staphylococcal Infections medicine.disease Toll-Like Receptor 2 Toll-Like Receptor 4 Staphylococcus aureus Tumor necrosis factor alpha Glucocorticoid medicine.drug |
| Zdroj: | Journal of Leukocyte Biology. 73:417-427 |
| ISSN: | 1938-3673 0741-5400 |
| DOI: | 10.1189/jlb.0702379 |
| Popis: | Although lack of adrenals dramatically reduces resistance against sepsis generally, the value of glucocorticoid levels above those normally produced by stress remains controversial. An early and long-held concept is that glucocorticoid protection against lipopolysaccharides in animal models is important. Supporting this concept, C3H/HeJ mice, lacking Toll-like receptor-4 (TLR-4), and consequently, endotoxin hyporesponsive, have recently been shown to be resistant to glucocorticoid protection against live Escherichia coli. Effective antibiotic intervention, as an additional parameter and with concomitant administration of glucocorticoid, not only allows for expected antibiotic protection but also for glucocorticoid protection against E. coli or Staphylococcus aureus of mice sensitized to tumor necrosis factor α, regardless of the status of the TLR-4 receptor. TLRs, including but not limited to TLR-2, may be involved in glucocorticoid protective efficacy against Gram-positive and Gram-negative sepsis. Overlapping and possibly endotoxin-independent signaling may become important considerations. |
| Databáze: | OpenAIRE |
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