Serum hormone levels in humans with low serum concentrations of 2,3,7,8-TCDD
| Autor: | Walter N. Piper, Lorelle L. Bestervelt, C Shorter, Donald G. Patterson, Larry L. Needham, Colleen J. Nolan, George W. Lucier, ES Johnson |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
0301 basic medicine
Adult Male endocrine system medicine.medical_specialty Thyroid Hormones Polychlorinated Dibenzodioxins Health Toxicology and Mutagenesis Population Endocrine System 010501 environmental sciences Toxicology Trichlorophenoxyacetic acid 01 natural sciences Glucagon 03 medical and health sciences Internal medicine Occupational Exposure medicine Humans heterocyclic compounds education Gonadal Steroid Hormones reproductive and urinary physiology Testosterone 0105 earth and related environmental sciences education.field_of_study Triiodothyronine 030102 biochemistry & molecular biology Chemistry Public Health Environmental and Occupational Health Agriculture Serum concentration Prolactin stomatognathic diseases Endocrinology Environmental Pollutants Public Health Hormone |
| Zdroj: | Toxicology and industrial health. 17(4) |
| ISSN: | 0748-2337 |
| Popis: | We measured current serum hormone and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) concentrations in 37 men who sprayed 2,4,5- trichlorophenoxyacetic acid (2,4,5-T) in the State of Victoria, Australia. TCDD levels were consistently significantly inversely related to prolactin levels in all analyses. In correlation analyses, TCDD levels were also inversely related to triiodothyronine (T3), thyroid-stimulating hormone (TSH), and testosterone levels, and positively associated with glucagon levels. The mean serum TCDD concentration in these sprayers was between 2.6 and 8.1 parts per trillion (ppt). Since such TCDD levels are commonly found in the general population in countries such as the US, the results could suggest that background levels of TCDD in the general population could have an effect on hormone levels. The findings are preliminary and need to be replicated in order to evaluate their full public health significance. |
| Databáze: | OpenAIRE |
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