Evaluation of Physicochemical Properties Following Syringe-to-Syringe Mixing of Hyaluronic Acid Dermal Fillers
| Autor: | Illyce Nuñez, Julius W. Few, Christopher K. Hee, Mitchel P. Goldman, Sandra Binauld, Aude Bernardin |
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| Rok vydání: | 2020 |
| Předmět: |
Filler (packaging)
Drug Compounding medicine.medical_treatment Mixing (process engineering) Cosmetic Techniques Dermatology Dermal Fillers 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Rheology medicine Anesthetics Local Hyaluronic Acid Saline Syringe Chromatography Chemistry Syringes Lidocaine General Medicine Dilution Drug Combinations 030220 oncology & carcinogenesis Surgery Extrusion Saline Solution Drug Contamination |
| Zdroj: | Dermatologic Surgery. 46:1606-1612 |
| ISSN: | 1524-4725 1076-0512 |
| DOI: | 10.1097/dss.0000000000002806 |
| Popis: | BACKGROUND Historically, soft-tissue hyaluronic acid (HA) fillers have been mixed with agents to reduce pain or alter physicochemical properties. OBJECTIVE Evaluate the impact of dilution and mixing on HA filler physicochemical properties. MATERIALS AND METHODS Crosslinked HA filler (VYC-20L, 20 mg/mL) was diluted to 15 mg/mL using saline through 5 or 10 passes between 2 syringes connected using a luer connector. Extrusion force, rheological properties, and microscopic appearance were assessed. Undiluted VYC-15L (15 mg/mL) served as the control. RESULTS Average extrusion force was higher for diluted VYC-20L versus the control, with an increase in slope for gel diluted using 5 passes (0.65) and 10 passes (0.52) versus the control ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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