Predicting organ carotenoids levels from analysis of plasma could lead to errors: A study in cynomolgus monkeys
| Autor: | Hiroyuki Yasui, Takashi Maoka, Takashi Ichihara, Kazuhisa Sugimoto, Azusa Nishino, Takashi Kuriki |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Antioxidant Endocrinology Diabetes and Metabolism medicine.medical_treatment Beta-Cryptoxanthin Physiology 030209 endocrinology & metabolism macromolecular substances Biology 03 medical and health sciences Human health Plasma 0302 clinical medicine Endocrinology Bias polycyclic compounds medicine Animals Humans Tissue Distribution Carotenoid composition Carotenoid Beneficial effects chemistry.chemical_classification Reactive oxygen species 030109 nutrition & dietetics Nutrition and Dietetics organic chemicals food and beverages Brain Carotenoids biological factors Diet Macaca fascicularis chemistry Research Design Fruits and vegetables Xanthophyll Models Animal |
| Zdroj: | Nutrition research (New York, N.Y.). 61 |
| ISSN: | 1879-0739 |
| Popis: | Carotenoids are phytochemicals with strong antioxidant activity against reactive oxygen species that are widely distributed in fruits and vegetables. The beneficial effects of carotenoids on human health have attracted considerable attention. The plasma carotenoid profile in humans is generally recognized to reflect the dietary carotenoid composition. Although carotenoid profile in plasma is believed to correlate well with that in other tissues, the data for tissue accumulation of carotenoids in humans is very limited and poorly understood. In order to test the hypothesis that blood carotenoids reflect tissue accumulation of dietary carotenoids, the cynomolgus monkey was used as a model to determine it's suitable for extrapolation of data on tissue accumulation of carotenoids to humans. Herein, plasma carotenoids were measured in cynomolgus monkeys given a dietary mixture of carotenoids. The findings indicate that cynomolgus monkeys and humans are similar with regard to preferential accumulation of β-cryptoxanthin in the blood and brain. These results suggested that cynomolgus monkeys could be used to collect data on tissue accumulation of carotenoids for extrapolation to humans. The tissue accumulation of carotenoids in other tissues of cynomolgus monkeys that have not yet been evaluated in humans were also investigated, revealing marked differences in carotenoid levels and composition among plasma and various monkey tissues. These results suggest that accumulation of carotenoids in plasma does not reflect necessarily that in tissues, so that predicting the tissue accumulation of carotenoids from plasma carotenoid levels and profiles alone could lead to errors. |
| Databáze: | OpenAIRE |
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