Disturbance of the Epithelial-Mesenchymal Transition as a Cause of the Defective Development of Human Spontaneous Abortions with Abnormal Karyotype
| Autor: | V. I. Kukharenko |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Epithelial-Mesenchymal Transition Abnormal Karyotype Trisomy 030105 genetics & heredity Nervous System Malformations General Biochemistry Genetics and Molecular Biology Cell Line 03 medical and health sciences medicine Humans Epithelial–mesenchymal transition Glycosaminoglycans biology Transition (genetics) digestive oral and skin physiology Embryogenesis Embryo Karyotype General Medicine medicine.disease Phenotype Fibronectins Cell biology Abortion Spontaneous Fibronectin 030104 developmental biology biology.protein Collagen |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 165:581-583 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Genetic program regulating epithelial-mesenchymal transition is activated at the early stages of embryogenesis. Abnormal karyotype of the embryo disrupts the fundamental process of epithelial-mesenchymal transition, which is seen from incomplete morphological rearrangement and reduced migration capacity of cells, as well as low level of expression of epithelial-mesenchymal transition markers (fibronectin, collagen, and glycosaminoglycans). Disturbances of the epithelial-mesenchymal transition affect the proliferative potential of cells with aberrant karyotype, which contributes to the delay of embryonic development and correlates with the formation of abnormal phenotype in carriers of chromosomal abnormalities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink