Prognostic impact of regression in patients with primary cutaneous melanoma >1 mm in thickness
| Autor: | Marcella Occelli, Paola Queirolo, Gerardo Botti, Luca Bertero, Giuseppe Palmieri, Anna Maria Di Giacomo, Laura Cattaneo, Pietro Quaglino, Ignazio Stanganelli, Vanna Chiarion Sileni, Paola Cassoni, Francesca Galli, Carlo Tondini, Mario Mandalà, Simone Ribero, Simona Osella-Abate, Daniela Massi, Barbara Merelli, Corrado Caracò, Vincenzo De Giorgi, Laura Ghilardi |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Male medicine.medical_specialty Multivariate statistics Multivariate analysis Skin Neoplasms melanoma-specific survival Sentinel lymph node Dermatology Disease-Free Survival Breslow Thickness 030207 dermatology & venereal diseases 03 medical and health sciences cutaneous melanoma 0302 clinical medicine sentinel lymph node Internal medicine medicine Humans disease-free interval outcome prognosis regression Female Melanoma Middle Aged Prognosis Remission Induction Retrospective Studies Survival Rate Tumor Burden Survival rate business.industry Hazard ratio Confidence interval 2708 030220 oncology & carcinogenesis Cutaneous melanoma business |
| Zdroj: | Journal of the American Academy of Dermatology 80 (2019): 99–105.e5. doi:10.1016/j.jaad.2018.06.054 info:cnr-pdr/source/autori:Ribero, Simone; Galli, Francesca; Osella-Abate, Simona; Bertero, Luca; Cattaneo, Laura; Merelli, Barbara; Tondini, Carlo; Ghilardi, Laura; De Giorgi, Vincenzo; Occelli, Marcella; Quaglino, Pietro; Cassoni, Paola; Palmieri, Giuseppe; Massi, Daniela; Mandala, Mario; Queirolo, Paola; Stanganelli, Ignazio; Botti, Gerardo; Caracò, Corrado; Chiarion Sileni, Vanna; Di Giacomo, Anna Maria/titolo:Prognostic impact of regression in patients with primary cutaneous melanoma >1 mm in thickness/doi:10.1016%2Fj.jaad.2018.06.054/rivista:Journal of the American Academy of Dermatology/anno:2019/pagina_da:99/pagina_a:105.e5/intervallo_pagine:99–105.e5/volume:80 |
| Popis: | Background: The impact of histologic regression on sentinel lymph node biopsy (SLNB) status and on clinical outcome is uncertain. Objective: To investigate whether and to what extent regression 1-mm thick. Methods: The study included patients with diagnoses given at 4 centers of the Italian Melanoma Intergroup. Univariate and multivariate Cox proportional hazard models stratified by center were used to analyze the effect of regression on disease-free interval and melanoma-specific survival. Results: Out of 1182 patients given primary cutaneous melanoma diagnoses during 1998-2015 with a Breslow thickness >1 mm, 954 (304 with and 650 without regression) were included in the analysis. The proportion of patients with a positive SLNB was lower in patients with regression than without (24.4% vs 31.6%, chi-squared test P =.0368). At multivariate analysis, no association was detected between regression and disease-free interval (hazard ratio 1.11, 95% confidence interval 0.85-1.46; P =.4509) or melanoma-specific survival (hazard ratio 1.05, 95% confidence interval 0.77-1.44; P =.7600). Limitation: Retrospective analysis. Conclusion: In our series, regression was not an independent prognostic factor in primary cutaneous melanoma patients with Breslow thickness >1 mm whereas it was associated with a lower incidence of SLNB positivity. |
| Databáze: | OpenAIRE |
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