Metabolic changes associated with sustained 48-Hr shivering thermogenesis in the newborn pig
| Autor: | Jean Le Dividich, R. Bertin, Delphine Berthon, Françoise de Marco, Patrick Herpin |
|---|---|
| Přispěvatelé: | Station de recherches porcines, Institut National de la Recherche Agronomique (INRA), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL) |
| Jazyk: | angličtina |
| Rok vydání: | 1996 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Epinephrine Physiology Swine [SDV]Life Sciences [q-bio] Adipose tissue Oxidative phosphorylation Biology Biochemistry Electron Transport Complex IV 03 medical and health sciences chemistry.chemical_compound Norepinephrine 0302 clinical medicine 030225 pediatrics Internal medicine Respiration medicine Animals Lactic Acid Respiratory system Molecular Biology Creatine Kinase 030304 developmental biology 0303 health sciences Lipoprotein lipase Glycogen Muscles Body Weight Shivering Mitochondria Muscle Lipoprotein Lipase Endocrinology chemistry Animals Newborn biology.protein Creatine kinase medicine.symptom Energy Metabolism |
| Zdroj: | Comparative Biochemistry and Physiology Part B: Comparative Biochemistry Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, Elsevier, 1996, 114B (4), pp.327-355. ⟨10.1016/0305-0491(96)00044-2⟩ |
| ISSN: | 0305-0491 |
| DOI: | 10.1016/0305-0491(96)00044-2⟩ |
| Popis: | International audience; Metabolic changes associated with sustained 48-hr shivering thermogenesis were studied in piglets maintained at 34 (thermoneutrality) or 25 degrees C (cold) between 6 and 54 hr of life. Despite their high shivering activity and elevated heat production, cold-exposed piglets exhibited a slightly lower rectal temperature than thermoneutral animals (-1.1 degrees C; P < 0.01) at the end of the treatment. The enhancement of heat production and shivering activity were associated with a decrease in muscle glycogen (-47%; P < 0.05) and total lipid content (-23%; P < 0.05), a reduction of blood lactate levels (P < 0.05) and an enhancement of muscle cytochrome oxidase activity (+20%; P < 0.05), which suggests that muscle oxidative potential was increased by cold exposure. Potential for capturing lipids (lipoprotein lipase activity) was also higher in the red rhomboideus muscle (+71%; P < 0.01) and lower in adipose tissue (-58%; P < 0.01) of the cold-exposed piglets. Measurements performed at the mitochondrial level show no changes in rhomboideus muscle, but respiratory capacities (state IV and FCCP-stimulated respiration) and intermyofibrillar mitochondria oxidative and phosphorylative (creatinine kinase activity) capacities were enhanced in longissimus dorsi muscle (P < 0.05). These changes may contribute to provide muscles with nonlimiting amount of readily oxidable substrates and ATP necessary for shivering thermogenesis. A rise in plasma norepinephrine levels was also observed during the second day of cold exposure (P < 0.05). |
| Databáze: | OpenAIRE |
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