Intraoperative blood salvage and retransfusion from citrate treated wounds is safe and feasible
| Autor: | P. Olsson, Kjell Rådegran, Christian Olsson, A. Öwall |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Blood transfusion Time Factors Swine medicine.medical_treatment Blood Loss Surgical Plasma Substitutes Hemodynamics Sodium Citrate Blood Transfusion Autologous medicine Animals Citrates Heart Atria Cardiac Surgical Procedures Whole blood Intraoperative Care business.industry Intraoperative blood salvage Pulmonary artery catheter Anticoagulants Surgical wound Crystalloid Solutions Haemolysis Surgery Anesthesia Models Animal Feasibility Studies Isotonic Solutions Cardiology and Cardiovascular Medicine business Biomarkers Autotransfusion |
| Zdroj: | Scandinavian cardiovascular journal : SCJ. 44(3) |
| ISSN: | 1651-2006 |
| Popis: | Allogenic blood transfusions are associated with increased morbidity and mortality in surgical patients. The study objective was to investigate the feasibility and safety of intraoperative autotransfusion of unwashed shed whole blood using a novel method.Twenty pigs were randomised to autotransfusion or crystalloid volume replacement. In two separate surgical wounds, the surfaces and 400 ml of shed blood were treated in situ with citrate, delivered with an equipment transforming suction to positive pressure. Central haemodynamics were monitored with a pulmonary artery catheter. Effects on oxygen-carrying capacity, formed blood elements, haemolysis, inflammation, metabolism, and coagulation were evaluated with biochemical analyses.No clinically relevant adverse effects on haemodynamics were encountered, apart from a decrease in cardiac output and mixed venous saturation similar to that in control animals. Haemoglobin level was better preserved in the autotransfused group (97 vs. 86 g/L, p=0.0007). There were no major differences in biochemical variables and no macroscopic clot formation precluding autotransfusion.The technique was safe and feasible for intraoperative blood salvage and autotransfusion. Haemodynamics and biochemical variables were similar to controls. The technique warrants further studies in humans, as it may contribute towards a reduction of allogenic blood transfusions. |
| Databáze: | OpenAIRE |
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