Transition of polycythemia vera to chronic myeloid leukaemia
| Autor: | Claudia Fiorani, Paola Temperani, Alessia Saviola, Patrizia Zucchini, Giuseppe Longo, Valeria Mazzocchi, Giovanni Emilia, Leonardo Ferrara, Giuseppe Torelli |
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| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Ph chromosome
Transition (genetics) business.industry Hematology General Medicine medicine.disease Chronic myeloid leukaemia Myeloproliferative disorders Polycythemia vera Transition Myeloproliferative Disorders hemic and lymphatic diseases Leukemia Myelogenous Chronic BCR-ABL Positive Immunology medicine Humans Hydroxyurea Female business Polycythemia Vera Aged |
| Popis: | A 77-year-old female with polycythemia vera (PV) showed a sudden, typical chronic myeloid leukaemia (CML), 8 yr after the initial diagnosis, and an intermittent treatment with hydroxyurea (0.5-1 g/d) and phlebotomies. At PV diagnosis, the Ph chromosome was negative and no ber-abl rearrangement was observed; they were both revealed positive at CML onset. Transition of PV to CML is very rare; only seven substantiated cases had been reported in the literature up until now (six from 1964 to 1993). All patients but one received 3 2 P or alkylating agents for PV treatment. The pathogenetic mechanisms are briefly discussed. |
| Databáze: | OpenAIRE |
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