Exhaled nitric oxide and bronchial wall thickening in asthmatics during and after acute exacerbation: evidence of bronchial wall remodeling
Autor: | Loren H. Ketai, Gary K. Iwamoto, Karen-Lynn Fiato, Michelle Harkins |
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Rok vydání: | 2005 |
Předmět: |
Spirometry
Pulmonary and Respiratory Medicine Adult Male Pathology medicine.medical_specialty Exacerbation Inflammation Bronchi Critical Care and Intensive Care Medicine Nitric Oxide Severity of Illness Index Nitric oxide chemistry.chemical_compound Adrenal Cortex Hormones Internal medicine Forced Expiratory Volume Immunology and Allergy Medicine Humans Asthma Bronchial wall medicine.diagnostic_test business.industry respiratory system medicine.disease respiratory tract diseases Treatment Outcome chemistry Exhalation Pediatrics Perinatology and Child Health Exhaled nitric oxide Acute Disease Cardiology Female Thickening medicine.symptom Bronchial Hyperreactivity Airway Cardiology and Cardiovascular Medicine business Tomography X-Ray Computed Follow-Up Studies |
Zdroj: | The Journal of asthma : official journal of the Association for the Care of Asthma. 42(8) |
ISSN: | 0277-0903 |
Popis: | To assess whether bronchial wall thickening during asthma exacerbations is due to active inflammation in severe asthmatics, we measured bronchial wall thickness and exhaled nitric oxide (FeNO) following treatment. Nine asthmatics were compared with seven controls with high-resolution computed tomography, spirometry, and FeNO measurements. The asthmatic bronchial wall area percent and FeNO was greater than controls. Following treatment, the FEV1 markedly improved, FeNO decreased modestly, and bronchial wall area percent did not change significantly. Bronchial wall thickening persisted after treatment of acute asthma exacerbation despite improvement in spirometry and decline in FeNO, possibly due to chronic airway remodeling. |
Databáze: | OpenAIRE |
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