Exhaled nitric oxide and bronchial wall thickening in asthmatics during and after acute exacerbation: evidence of bronchial wall remodeling

Autor: Loren H. Ketai, Gary K. Iwamoto, Karen-Lynn Fiato, Michelle Harkins
Rok vydání: 2005
Předmět:
Zdroj: The Journal of asthma : official journal of the Association for the Care of Asthma. 42(8)
ISSN: 0277-0903
Popis: To assess whether bronchial wall thickening during asthma exacerbations is due to active inflammation in severe asthmatics, we measured bronchial wall thickness and exhaled nitric oxide (FeNO) following treatment. Nine asthmatics were compared with seven controls with high-resolution computed tomography, spirometry, and FeNO measurements. The asthmatic bronchial wall area percent and FeNO was greater than controls. Following treatment, the FEV1 markedly improved, FeNO decreased modestly, and bronchial wall area percent did not change significantly. Bronchial wall thickening persisted after treatment of acute asthma exacerbation despite improvement in spirometry and decline in FeNO, possibly due to chronic airway remodeling.
Databáze: OpenAIRE
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