Different effects of (+)-borneol and (−)-borneol on the pharmacokinetics of osthole in rats following oral administration
| Autor: | Yu-Hong Liu, Xiao‑Ying Chen, Zi-Ren Su, Xiu‑Fen Wang, Yi-Feng Zheng, Zhen‑Biao Zhang, Qi Wang, Dan‑Dan Luo, Chao‑Yue Sun, Janis Ya-Xian Zhan |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Cancer Research Cmax Administration Oral Pharmacology 030226 pharmacology & pharmacy Biochemistry High-performance liquid chromatography Gastrointestinal absorption Borneol Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pharmacokinetics Coumarins Oral administration Active component CNIDIUM MONNIERI FRUIT Genetics Animals Medicine Medicine Chinese Traditional Molecular Biology Camphanes business.industry Rats 030104 developmental biology Oncology chemistry Area Under Curve Molecular Medicine business Drugs Chinese Herbal |
| Zdroj: | Molecular Medicine Reports. 15:4239-4246 |
| ISSN: | 1791-3004 1791-2997 |
| DOI: | 10.3892/mmr.2017.6502 |
| Popis: | Osthole is the primary active component of a number of herbal plants such as the Cnidium monnieri fruit. In traditional Chinese herb medicine, osthole is commonly used in combination with borneol to obtain improved pharmacological effects. The aim of the present study was to investigate the effect of borneol enantiomers on the pharmacokinetics of osthole. An appropriate high‑performance liquid chromatography (HPLC) method was applied to determine the concentrations of osthole in plasma. Following oral administration of osthole alone or combined with borneol in rats, blood samples were collected and analyzed by HPLC. The results demonstrated that there were statistically significant differences in the pharmacokinetic parameters of osthole between osthole administration alone and co‑administration with borneol. When combined with synthetic borneol, the AUC0‑t, AUC0‑∞ and Cmax of osthole increased by 48.153, 104.708 and 92.630%, respectively, while the CL/F decreased by 51.251%. When combined with (+)‑borneol, the AUC0‑t, AUC0‑∞ and Cmax of osthole were increased by 61.561, 78.167, and 51.769%, respectively, while the CL/F decreased by 44.174% (P |
| Databáze: | OpenAIRE |
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