The association of dietary flavonoids, magnesium and their interactions with the metabolic syndrome in Chinese adults: a prospective cohort study
| Autor: | Tianshu Han, Junyi Liu, lixin na, Changhao Sun, Shanshan Jin, Xiujuan Zhao, Yubing Jia |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty China Medicine (miscellaneous) 030209 endocrinology & metabolism Lower risk Gastroenterology 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Risk Factors Internal medicine medicine Humans Magnesium Obesity Prospective Studies Kaempferols Prospective cohort study Luteolin Isorhamnetin Aged Flavonoids Metabolic Syndrome 030109 nutrition & dietetics Nutrition and Dietetics business.industry Polyphenols Middle Aged medicine.disease Diet chemistry Relative risk Obesity Abdominal Quercetin Metabolic syndrome business Cohort study |
| Zdroj: | The British journal of nutrition. 126(6) |
| ISSN: | 1475-2662 |
| Popis: | The aim was to systematically analyse the association of the specific flavonoids, Mg and their interactions from different food sources with the metabolic syndrome (MetS) and its components in a cohort study. A total of 6417 participants aged 20 to 74 years from the Harbin Cohort Study on Diet, Nutrition and Chronic Non-communicable Diseases were included. Multivariate logistic regression analyses, forest plot and restricted cubic spline were performed in the study. After a 5·3-year follow-up, 1283 incident cases of the MetS were reported. Those with a higher total flavonoid intake had a lower risk of the MetS (fourth v. first quartile, relative risk (RR) 0·58; 95 % CI 0·37, 0·93; P = 0·024) and central obesity (RR 0·56; 95 % CI 0·33, 0·95; P = 0·032). Further analysis showed that the specific flavonoids quercetin, kaempferol, isorhamnetin, luteolin, and flavonoids from fruits, potatoes and legumes had the similar associations with risk of the MetS and central obesity (P < 0·05 for all). A higher intake of total flavonoids, quercetin and luteolin combined with a high level of Mg was more strongly associated with a lower risk of the MetS (RR 0·60; 95 % CI 0·45, 0·81 for total; RR 0·61; 95 % CI 0·45, 0·82 for quercetin; RR 0·52; 95 % CI 0·38, 0·71 for luteolin; all Pfor interaction < 0·01). Dose–response effects showed an L-shaped curve between the total intake of five flavonoids and the risk of the MetS. A higher flavonoid intake is associated with a lower risk of the MetS and central obesity; their combination with Mg helps to strengthen their negative association with the MetS. |
| Databáze: | OpenAIRE |
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