Antiviral Therapy Reduces Risk of Cirrhosis in Noncirrhotic HBV Patients Among 4 Urban Safety-Net Health Systems
| Autor: | Mae Thamer, Onkar Kshirsagar, Robert J Wong, Mamta K Jain, George Therapondos, Bolin Niu |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Carcinoma Hepatocellular Guanine Cirrhosis Urban Population Kaplan-Meier Estimate Lower risk Antiviral Agents White People 03 medical and health sciences Hepatitis B Chronic 0302 clinical medicine Internal medicine medicine Humans Mortality Propensity Score Tenofovir Aged Proportional Hazards Models Retrospective Studies Alanine Asian Hepatology Proportional hazards model business.industry Liver Neoplasms Hazard ratio Gastroenterology Middle Aged medicine.disease United States Confidence interval Black or African American 030220 oncology & carcinogenesis Hepatocellular carcinoma Cohort Female 030211 gastroenterology & hepatology Diagnosis code business Safety-net Providers |
| Zdroj: | American Journal of Gastroenterology. 116:1465-1475 |
| ISSN: | 1572-0241 0002-9270 |
| DOI: | 10.14309/ajg.0000000000001195 |
| Popis: | INTRODUCTION To evaluate the impact of chronic hepatitis B virus infection (CHB) treatment on risk of cirrhosis, liver-related outcomes, and death among a diverse CHB cohort with a large proportion of African Americans. METHODS Adults with noncirrhotic CHB without human immunodeficiency virus from 2010 to 2018 were retrospectively evaluated across 4 US safety-net health systems. CHB was identified with International Classification of Diseases, Ninth Revision/Tenth Revision diagnosis coding and confirmatory laboratory data. Propensity-score matching, Kaplan-Meier methods, and adjusted Cox proportional hazards models were used to evaluate impact of CHB treatment on risk of cirrhosis, hepatocellular carcinoma (HCC), death, and composite of cirrhosis, HCC, or death. RESULTS Among 4,064 CHB patients (51.9% female, 42.0% age |
| Databáze: | OpenAIRE |
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