Plasma levels of p53 protein and chromosomal aberrations in patients with psoriasis treated with the Goeckerman regimen
| Autor: | Lenka Kotingová, Jan Kremlacek, D. Ranna, Ctirad Andrys, Zdenek Fiala, K. Hamakova, Lenka Borska, Jan Krejsek |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Goeckerman regimen medicine.medical_specialty Adolescent Dermatology Biology Administration Cutaneous Risk Assessment Dermal exposure Gastroenterology Young Adult Psoriasis Area and Severity Index Psoriasis Internal medicine medicine Humans In patient Coal Tar Aged Chromosome Aberrations Plasma levels Middle Aged medicine.disease Immunology P53 protein After treatment |
| Zdroj: | Clinical and Experimental Dermatology. 34:e881-e883 |
| ISSN: | 1365-2230 0307-6938 |
| DOI: | 10.1111/j.1365-2230.2009.03648.x |
| Popis: | Summary The Goeckerman regimen (GR) is one of the oldest effective treatments for psoriasis. It involves daily dermal application of crude coal tar with dermal exposure to ultraviolet (UV) radiation. A study was carried out to evaluate the genotoxic risk of GR by comparing p53 protein plasma level and chromosomal aberrations (CA) in peripheral lymphocytes in 33 patients with psoriasis, before and after GR. Psoriasis Area and Severity Index (PASI) was used to evaluate the efficacy of GR. PASI significantly decreased after GR (P |
| Databáze: | OpenAIRE |
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