A Ser315Thr Substitution in KatG Is Predominant in Genetically Heterogeneous Multidrug-Resistant Mycobacterium tuberculosis Isolates Originating from the St. Petersburg Area in Russia
| Autor: | Tatjana F. Otten, Elena Vyshnevskaya, Harri Marttila, Matti K. Viljanen, Erkki Eerola, Hanna Soini, Boris Vyshnevskiy, Alexandr V. Vasilyef |
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| Rok vydání: | 1998 |
| Předmět: |
Drug resistance
Microbiology Mycobacterium tuberculosis Bacterial Proteins Mechanisms of Resistance Isoniazid medicine Humans Pharmacology (medical) Multidrug-Resistant Mycobacterium tuberculosis Pharmacology Genetics biology biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification rpoB Drug Resistance Multiple respiratory tract diseases Infectious Diseases Peroxidases Mutation bacteria Rifampin Restriction fragment length polymorphism Bacteria Rifampicin medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 42:2443-2445 |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | Parts of katG and rpoB from 27 Russian Mycobacterium tuberculosis isolates were sequenced to detect mutations causing resistance to isoniazid (INH) and rifampin (RMP), respectively. All 24 INH-resistant isolates had a mutated katG , and 22 of them (91.7%) carried a mutation coding for a Ser315Thr shift. An rpoB mutation was noted for each of the 21 RMP-resistant isolates, with Ser531Leu being the most prevalent change encoded. Only two isolates had identical IS 6110 fingerprints. |
| Databáze: | OpenAIRE |
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