Role of antioxidant systems in induced nutritional pancreatic atrophy in chicken
| Autor: | Cássio Xavier de Mendonça Júnior, Marcelo Cerqueira César, José Luis Avanzo |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Antioxidant Physiology medicine.medical_treatment chemistry.chemical_element medicine.disease_cause Thiobarbituric Acid Reactive Substances Biochemistry Antioxidants Selenium chemistry.chemical_compound Internal medicine medicine TBARS Animals Vitamin E Pancreas Molecular Biology chemistry.chemical_classification Glutathione Catalase Mitochondria Oxygen Oxidative Stress Enzyme Endocrinology medicine.anatomical_structure chemistry Animal Nutritional Physiological Phenomena Lipid Peroxidation Atrophy Chickens Oxidative stress |
| Zdroj: | Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 131:815-823 |
| ISSN: | 1096-4959 |
| DOI: | 10.1016/s1096-4959(02)00040-4 |
| Popis: | One-day-old chicks were reared using diets differing in their vitamin E and/or selenium content. The purpose of this research was to detect any possible imbalance in the antioxidant defense system, which could be related to development of nutritional pancreatic atrophy. Mitochondrial membranes from animals deficient in both nutrients, or just vitamin E, submitted to peroxidizability ‘in vitro’ had the production of TBARS greatly enhanced. Measurements of the 2-GSH/GSSG ratio suggested that selenium and vitamin E, the latter in higher magnitude, were responsible for maintenance of the reducing capacity of the cell. Enzymatic defense systems against oxidative stress were also studied. The results indicated that the total antioxidant enzymatic activity of pancreatic cells was not sufficient to scavenge all the ROS generated in the nutritionally deficient animals. The present study suggests that nutritional deficiency of selenium and/or vitamin E generates one imbalance between pro-oxidant and antioxidant systems in chicken pancreas, leading to oxidative stress and pancreatic atrophy. |
| Databáze: | OpenAIRE |
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