Neural tuning for sound duration: role of inhibitory mechanisms in the inferior colliculus
| Autor: | John H. Casseday, Ellen Covey, Daphna Ehrlich |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Inferior colliculus
Time Factors Central nervous system Glycine Action Potentials Inhibitory postsynaptic potential Bicuculline Models Biological Chiroptera medicine Animals gamma-Aminobutyric Acid Neurons Multidisciplinary Chemistry Neural integration Anatomy Strychnine Auditory midbrain Inferior Colliculi Electrophysiology medicine.anatomical_structure Acoustic Stimulation Duration (music) Excitatory postsynaptic potential Auditory Perception Neuroscience |
| Zdroj: | Science (New York, N.Y.). 264(5160) |
| ISSN: | 0036-8075 |
| Popis: | Duration is a biologically important feature of sound. Some neurons in the inferior colliculus of the big brown bat, Eptesicus fuscus, are tuned to sound duration, but it is unclear at what level the tuning originates or what neural mechanisms are responsible for it. The application of antagonists of the inhibitory neurotransmitters gamma-aminobutyric acid or glycine to neurons in the inferior colliculus eliminated duration tuning. Whole-cell patch-clamp recordings of synaptic currents suggested that inhibition produces a temporal frame within which excitation can occur. A model is proposed in which duration tuning arises when an early, sustained inhibitory input interacts with a delayed, transient excitatory input. |
| Databáze: | OpenAIRE |
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