Chemotherapy for Carcinomain situof the Bladder
| Autor: | D. F. Badenoch, R. T. D. Oliver, R. C. Tiptaft, J.P. Blandy, C. G. Fowler, A. M. I. Paris, B. J. Jenkins, H.R. England |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Male medicine.medical_specialty Cyclophosphamide Mitomycin Urology medicine.medical_treatment Mitomycins Cystectomy Humans Medicine Radical surgery Aged Aged 80 and over Chemotherapy business.industry Carcinoma in situ Mitomycin C Cancer Middle Aged medicine.disease Combined Modality Therapy Surgery Radiation therapy Administration Intravesical Urinary Bladder Neoplasms Injections Intravenous Female business Carcinoma in Situ Follow-Up Studies medicine.drug |
| Zdroj: | British Journal of Urology. 61:326-329 |
| ISSN: | 1464-410X 0007-1331 |
| DOI: | 10.1111/j.1464-410x.1988.tb13967.x |
| Popis: | Summary— In an 8-year period, 71 patients were diagnosed as having carcinoma in situ of the bladder. Twenty patients with primary carcinoma in situ were treated with systemic cyclophosphamide or intravesical mitomycin C and 19 of them survived 3 years. Three patients required cystectomy: 1 for invasive cancer and 2 for intractable symptoms in the absence of tumour. Fifty-one patients had either secondary or concomitant carcinoma in situ. Systemic or intravesical chemotherapy was given to 28 patients in whom carcinoma in situ was associated with G1 or G2 exophytic superficial tumour: there was only one cancer death in 3 years. Fifteen patients with G3 carcinoma in situ associated with a G3 or invasive exophytic tumour were treated with radiotherapy: 9 responded but 4 of the 6 with radio-insensitive tumours died of cancer within 3 years. Eight patients with secondary carcinoma in situ were managed by transurethral resection alone: in 6 there was spontaneous regression and 2 developed muscle invasion within 1 year. These results compare well with those of immunotherapy or early radical surgery and suggest that chemotherpy should be given a trial in patients with carcinoma in situ. |
| Databáze: | OpenAIRE |
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