Broncho alveolar dendritic cells and macrophages are highly similar to their interstitial counterparts

Autor: Edwige Bouguyon, Nicolas Bertho, Elise Bordet, Pauline Maisonnasse
Přispěvatelé: Unité de recherche Virologie et Immunologie Moléculaires (VIM), Institut National de la Recherche Agronomique (INRA), Fondation du souffle, Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Bertho, Nicolas
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Pathology
Lung Development
Pulmonology
Physiology
Organogenesis
[SDV]Life Sciences [q-bio]
lcsh:Medicine
Pathology and Laboratory Medicine
White Blood Cells
lavage broncho alvéolaire
Animal Cells
Broncho-alveolar
Human medicine
Medicine and Health Sciences
Respiratory system
Alveolar Macrophages
Intestinal Mucosa
lcsh:Science
Immune Response
interstitial cell
Multidisciplinary
medicine.diagnostic_test
monocyte-derived macrophages
respiratory system
Flow Cytometry
3. Good health
Intestines
Models
Animal
cellule dendritique
Cellular Types
Bronchoalveolar Lavage Fluid
Research Article
medicine.medical_specialty
expression génique
Immune Cells
Immunology
Antigen-Presenting Cells
macrophage
interdigitating cell
03 medical and health sciences
Animal model
Signs and Symptoms
cellule interstitielle
Diagnostic Medicine
man
Macrophages
Alveolar
medicine
Genetics
Animals
Respiratory Physiology
Inflammation
Blood Cells
business.industry
Macrophages
lcsh:R
Biology and Life Sciences
Correction
swine
Cell Biology
Dendritic Cells
030104 developmental biology
Bronchoalveolar lavage
Respiratory Infections
gene expression
lcsh:Q
business
humain
Organism Development
Developmental Biology
porc
Zdroj: PLoS ONE
PLoS ONE, Public Library of Science, 2016, 11 (12), ⟨10.1371/journal.pone.0167315⟩
PLoS ONE, Vol 11, Iss 12, p e0167315 (2016)
Plos One 12 (11), . (2016)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0167315⟩
Popis: Erratum inCorrection: Broncho Alveolar Dendritic Cells and Macrophages Are Highly Similar to Their Interstitial Counterparts. [PLoS One. 2017]Correct Name of the funding Statement : Fondation du Souffle; In human medicine, bronchoalveolar lavage is the main non-traumatic procedure allowing an insight into the respiratory Dendritic Cells (DC) and Macrophages populations. However, it has never been demonstrated in a relevant model that alveolar DC subpopulations were comparable to their interstitial counterparts. In a precedent work we observed that respiratory pig DC and Macrophages were more similar to the human ones than to the mouse ones. In the present work, thanks to our animal model, we were able to collect the rare bronchoalveolar DC and compare them to their interstitial counterparts. We observed that DC presented very similar gene-expression patterns in the alveolar and interstitial compartments, validating the study of human bronchoalveolar DC as surrogate of their interstitium counterparts.
Databáze: OpenAIRE
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