Differences in Global and Regional Left Ventricular Myocardial Mechanics in Various Morphologic Subtypes of Patients With Obstructive Hypertrophic Cardiomyopathy Referred for Ventricular Septal Myotomy/Myectomy
| Autor: | Zoran B. Popović, Maran Thamilarasan, Aditya Bhonsale, Harry M. Lever, Bruce W. Lytle, Nicholas G. Smedira, Ashwat Dhillon, Taisei Kobayashi, Milind Y. Desai |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Myotomy medicine.medical_specialty Systole Heart Ventricles medicine.medical_treatment Cardiomyopathy Diastole Concentric hypertrophy Ventricular Septum Ventricular Function Left Basal (phylogenetics) Internal medicine medicine Humans Cardiac Surgical Procedures business.industry Stroke Volume Stroke volume Cardiomyopathy Hypertrophic Middle Aged Prognosis medicine.disease Myocardial Contraction Echocardiography Doppler Cardiology Female Obstructive hypertrophic cardiomyopathy Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | The American Journal of Cardiology. 113:1879-1885 |
| ISSN: | 0002-9149 |
| Popis: | Patients with obstructive hypertrophic cardiomyopathy (HC) have various left ventricular (LV) shapes: reverse septal curvature (RSC, commonly familial), sigmoid septum (SS, common in hypertensives), and concentric hypertrophy (CH). Longitudinal (systolic and early diastolic) strain rate (SR) is sensitive in detecting regional myocardial dysfunction. We sought to determine differences in longitudinal SR of patients with obstructive HC, based on LV shapes. We studied 199 consecutive patients with HC (50% men) referred for surgical myectomy. Clinical and echocardiographic parameters were recorded. LV shapes were classified on echocardiography, using basal septal 1/3 to posterior wall ratio: RSC = ratio1.3 (extending to mid and distal septum), SS = ratio1.3 (extending only to basal 1/3), and concentric = ratio ≤1.3. Longitudinal systolic and early diastolic SRs were measured from apical 4- and 2-chamber views (VVI 2.0; Siemens, Erlangen). Distribution of RSC, SS, and CH was 50%, 28%, and 22%, respectively. Patients with RSC were significantly younger (47 ± 12 vs 64 ± 10 and 57 ± 11, respectively) with lower hypertension (40% vs 71% and 67%, respectively) than patients with SS or CH (both p0.001). Patients with RSC had lower global systolic (-0.99 ± 0.3 vs -1.05 ± 0.3 and -1.17 ± 0.3) and early diastolic SR (0.95 ± 0.4 vs 0.98 ± 0.3 and 1.16 ± 0.4) versus patients with SS and CH (in 1/s, both p0.01), despite being much younger and less hypertensive. RSC was associated with abnormal global LV systolic (beta 0.16) and early diastolic (beta -0.17) SR (both p0.01). In conclusion, patients with HC with RCS have significantly abnormal LV mechanics, despite being younger and less hypertensive. A combination of LV mechanics and shapes could help differentiate between genetically mediated and other causes of obstructive HC. |
| Databáze: | OpenAIRE |
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