Seronegative invasive gastro-intestinal cytomegalovirus disease in renal allograft recipients a diagnostic dilemma! – Tissue PCR the saviour?
| Autor: | S Mohendra, Sukanta Barai, Awadhesh Kumar, Vivek Ruhela, Anupma Kaul, Narayan Prasad, Vikas Agarwal, R.K. Sharma, Annapurna Gupta, Dharmendra Bhadauria |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Microbiology (medical) Pathology medicine.medical_specialty Cytomegalovirus disease invasive Biopsy gastrointerstinal disaese lcsh:QR1-502 Cytomegalovirus Viremia Disease Polymerase Chain Reaction lcsh:Microbiology Endoscopy Gastrointestinal Organ transplantation renal transplant medicine Humans Cytomegalovirus disease medicine.diagnostic_test business.industry gastrointerstinal virus diseases Middle Aged medicine.disease Kidney Transplantation Transplant Recipients Gastroenteritis Endoscopy Cytomegalovirus Infections DNA Viral Renal allograft Histopathology business |
| Zdroj: | Indian Journal of Medical Microbiology, Vol 33, Iss 3, Pp 447-452 (2015) |
| ISSN: | 0255-0857 |
| DOI: | 10.4103/0255-0857.158596 |
| Popis: | Seronegative Invasive Gastro-intestinal cytomegalovirus disease in renal allograft recipients Background -CMV as oppurtunistic infection affecting the gastrointerstinal tract is the most common cause for tissue invasive CMV disease occuring in 10-30% of organ transplant recepients. Gastrointerstinal CMV disease can be diagnosed in presence of clinical suspecion along with histopathological findings (CMV inclusions) and presence of mucosal lesion(s) on endoscopic examination with collaborative evidences via molecular technique. Aims-Few cases of CMV infection affecting the gastrointerstinal tract show no evidences of dissemintion despite use of highly sensitive molecular techniques. We encountered 6 cases where in despite strong clinical suspecion of Gastrointerstinal CMV disease there were seronegative and endoscopic negative evidences for CMV, blind tissue biopsy yeilded positive results for CMV disease with excellent improvement with antiviral therapy. Conclusions-Blind biopsy specimen for tissue PCR could serve as saviour in an immunocompromised individiual who has a strong clinical symptomatology for GI-CMV disease in absence of viremia, normal endoscopy and histopathology, so that the early therapeutic interventions could help in excellent patient and graft survival. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect