Pupillometric findings in patients with Parkinson's disease and cognitive disorder
| Autor: | Bettina Haidich, Dimitrios Tsiptsios, Maria Nakou, Anna Karlovasitou, Charalambos Giantselidis, Dimitrios Fotiou, Vasilios Stergiou |
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| Rok vydání: | 2009 |
| Předmět: |
Miosis
medicine.medical_specialty Light Audiology Reflex Pupillary Pupil Central nervous system disease Physiology (medical) Reaction Time medicine Humans Psychiatry Aged Aged 80 and over Analysis of Variance Mini–Mental State Examination medicine.diagnostic_test General Neuroscience Cognitive disorder Wechsler Adult Intelligence Scale Parkinson Disease medicine.disease Neuropsychology and Physiological Psychology medicine.symptom Cognition Disorders Psychology Anxiety disorder Pupillometry |
| Zdroj: | International Journal of Psychophysiology. 72:97-101 |
| ISSN: | 0167-8760 |
| DOI: | 10.1016/j.ijpsycho.2008.10.010 |
| Popis: | The aim of this study is to investigate the changes of the pupil's light reflex (PLR) and mobility in Parkinson's disease (PD) patients with and without cognitive disorder. Twenty two (22) patients (ten males, twelve females, mean age: 72.7+/-7.3 years) with identified PD entered the study. The patients were examined with the Mini Mental State Examination (MMSE), the Wechsler II Memory Scale (WMS II) and the Hamilton Depression Scale (HAM-D17). Eleven (11) patients (five males, six females, mean age: 72.09+/-7.06 years) were free of any cognitive deficits and eleven (11) patients (five males, six females, mean age: 73.36+/-7.55 years) had cognitive disorder according to the aforementioned scales. None of the patients satisfied the DSM-IV-TR criteria for depression or anxiety disorder. The patients underwent a pupillometric study in both eyes with single flash stimuli of 24.6 candelas/m(2) intensity and 20 ms duration. The pupillometric parameters that were studied were: Latency for the onset of Constriction (T1), Baseline Pupil Radius (R1), Minimum Pupil Radius after the pupil reaction to light (R2), Amplitude (AMP, R1-R2), Time for maximum Miosis (T2), Maximum Constriction Velocity (VCmax) and Maximum Constriction Acceleration (ACmax). The pupillometric findings of each group were compared to those of an age and sex matched group of eleven healthy subjects. Furthermore, a comparison between the findings of the two groups was conducted. ACmax and VCmax were significantly lower in patients without (PD) and with coexisting cognitive impairment (PDC) compared to normal subjects (NC) (p |
| Databáze: | OpenAIRE |
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