Animal and translational models of SARS-CoV-2 infection and COVID-19
Autor: | Matt D. Johansen, Warwick J. Britton, Alexander J. Cole, Philip M. Hansbro, Richard Kim, X. Montagutelli, Gang Liu, David G. Le Couteur, Kirsty R. Short, Michelle D. Tate, J. G. Lyons, Alen Faiz, Ina Rudloff, Bernadette M. Saunders, Mark D. Gorrell, Brian G. Oliver, Peter A. B. Wark, Aaron T. Irving, James A. Triccas, Geoffrey W. McCaughan, Nicole G. Hansbro, Chantal Donovan, Marcel F. Nold, Daniel Hesselson, G. Gregory Neely, Stephen J. Simpson, Jennifer R. Gamble, Claudia A. Nold-Petry, Courtney C. Moreno |
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Přispěvatelé: | University of Technology Sydney (UTS), Zhejiang University School of Medicine [China], Génétique de la souris - Mouse Genetics, Institut Pasteur [Paris], Hudson Institute of Medical Research [Clayton], Monash University [Clayton], Monash Children’s Hospital [Clayton], University of Newcastle [Australia] (UoN), University of Queensland [Brisbane], Centenary Institute [Sidney], The University of Sidney, Institut Pasteur [Paris] (IP), University of Newcastle [Callaghan, Australia] (UoN) |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Male Disease Review Article Antibodies Viral Severity of Illness Index Animals Genetically Modified Mice 0302 clinical medicine Chiroptera Pandemic Immunology and Allergy Haplorhini 3. Good health Organoids Spike Glycoprotein Coronavirus [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology 06 Biological Sciences 11 Medical and Health Sciences Female Angiotensin-Converting Enzyme 2 Coronavirus Infections Pneumonia (non-human) medicine.medical_specialty COVID-19 Vaccines Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Immunology Pneumonia Viral Peptidyl-Dipeptidase A Antiviral Agents 03 medical and health sciences Betacoronavirus Cricetulus Species Specificity medicine Animals Humans Intensive care medicine Pandemics Competing interests business.industry SARS-CoV-2 Ferrets COVID-19 Viral Vaccines medicine.disease Clinical trial Coronavirus Disease Models Animal 030104 developmental biology Cats Disease manifestation business 030215 immunology |
Zdroj: | Mucosal Immunology Mucosal Immunology, Nature Pub. Group, 2020, Online ahead of print. ⟨10.1038/s41385-020-00340-z⟩ Mucosal Immunology, 2020, Online ahead of print. ⟨10.1038/s41385-020-00340-z⟩ |
ISSN: | 1933-0219 1935-3456 |
Popis: | This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.; International audience; COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical community is in a race to define and develop effective preventions and treatments. The major features of disease are described but clinical trials have been hampered by competing interests, small scale, lack of defined patient cohorts and defined readouts. What is needed now is head-to-head comparison of existing drugs, testing of safety including in the background of predisposing chronic diseases, and the development of new and targeted preventions and treatments. This is most efficiently achieved using representative animal models of primary infection including in the background of chronic disease with validation of findings in primary human cells and tissues. We explore and discuss the diverse animal, cell and tissue models that are being used and developed and collectively recapitulate many critical aspects of disease manifestation in humans to develop and test new preventions and treatments. |
Databáze: | OpenAIRE |
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