Animal and translational models of SARS-CoV-2 infection and COVID-19

Autor: Matt D. Johansen, Warwick J. Britton, Alexander J. Cole, Philip M. Hansbro, Richard Kim, X. Montagutelli, Gang Liu, David G. Le Couteur, Kirsty R. Short, Michelle D. Tate, J. G. Lyons, Alen Faiz, Ina Rudloff, Bernadette M. Saunders, Mark D. Gorrell, Brian G. Oliver, Peter A. B. Wark, Aaron T. Irving, James A. Triccas, Geoffrey W. McCaughan, Nicole G. Hansbro, Chantal Donovan, Marcel F. Nold, Daniel Hesselson, G. Gregory Neely, Stephen J. Simpson, Jennifer R. Gamble, Claudia A. Nold-Petry, Courtney C. Moreno
Přispěvatelé: University of Technology Sydney (UTS), Zhejiang University School of Medicine [China], Génétique de la souris - Mouse Genetics, Institut Pasteur [Paris], Hudson Institute of Medical Research [Clayton], Monash University [Clayton], Monash Children’s Hospital [Clayton], University of Newcastle [Australia] (UoN), University of Queensland [Brisbane], Centenary Institute [Sidney], The University of Sidney, Institut Pasteur [Paris] (IP), University of Newcastle [Callaghan, Australia] (UoN)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Disease
Review Article
Antibodies
Viral
Severity of Illness Index
Animals
Genetically Modified
Mice
0302 clinical medicine
Chiroptera
Pandemic
Immunology and Allergy
Haplorhini
3. Good health
Organoids
Spike Glycoprotein
Coronavirus
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
06 Biological Sciences
11 Medical and Health Sciences
Female
Angiotensin-Converting Enzyme 2
Coronavirus Infections
Pneumonia (non-human)
medicine.medical_specialty
COVID-19 Vaccines
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Immunology
Pneumonia
Viral
Peptidyl-Dipeptidase A
Antiviral Agents
03 medical and health sciences
Betacoronavirus
Cricetulus
Species Specificity
medicine
Animals
Humans
Intensive care medicine
Pandemics
Competing interests
business.industry
SARS-CoV-2
Ferrets
COVID-19
Viral Vaccines
medicine.disease
Clinical trial
Coronavirus
Disease Models
Animal
030104 developmental biology
Cats
Disease manifestation
business
030215 immunology
Zdroj: Mucosal Immunology
Mucosal Immunology, Nature Pub. Group, 2020, Online ahead of print. ⟨10.1038/s41385-020-00340-z⟩
Mucosal Immunology, 2020, Online ahead of print. ⟨10.1038/s41385-020-00340-z⟩
ISSN: 1933-0219
1935-3456
Popis: This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.; International audience; COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical community is in a race to define and develop effective preventions and treatments. The major features of disease are described but clinical trials have been hampered by competing interests, small scale, lack of defined patient cohorts and defined readouts. What is needed now is head-to-head comparison of existing drugs, testing of safety including in the background of predisposing chronic diseases, and the development of new and targeted preventions and treatments. This is most efficiently achieved using representative animal models of primary infection including in the background of chronic disease with validation of findings in primary human cells and tissues. We explore and discuss the diverse animal, cell and tissue models that are being used and developed and collectively recapitulate many critical aspects of disease manifestation in humans to develop and test new preventions and treatments.
Databáze: OpenAIRE
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