Synthesis of both enantiomers of lycoperdic acid, an unusual mushroom-derived amino acid

Autor: Mikiko Kunisawa, Ryutaro Ishiuchi, Ryo Katsuta, Ken Ishigami, Tomoo Nukada, Arata Yajima
Rok vydání: 2021
Předmět:
Zdroj: Bioscience, Biotechnology, and Biochemistry. 85:154-159
ISSN: 1347-6947
DOI: 10.1093/bbb/zbaa027
Popis: An efficient synthesis of both enantiomers of lycoperdic acid, a 4-hydroxyglutamic acid derivative from edible mushroom Lycoperdon perlatum, was achieved from a chiral aminoalcohol. The key steps were a stereoselective introduction of a C3 unit into a bicyclic ketone and oxidative cleavage of a cyclic vicinal diol into a dicarboxylic acid. This report provides the first synthesis of (−)-lycoperdic acid.
Databáze: OpenAIRE
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