Thermodynamic stability, in-vitro permeability, and in-silico molecular modeling of the optimal Elaeis guineensis leaves extract water-in-oil nanoemulsion
| Autor: | Nurul Huda, Nissha Bharrathi Romes, Rovina Kobun, Roswanira Abdul Wahab, Habeebat Adekilekun Oyewusi, Mariani Abdul Hamid |
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| Rok vydání: | 2021 |
| Předmět: |
Models
Molecular Molecular biology Science medicine.medical_treatment Skin Absorption Arecaceae Elaeis guineensis Administration Cutaneous Permeability Article chemistry.chemical_compound Engineering Nanoscience and technology Stratum corneum medicine Humans Gallic acid Skin Multidisciplinary Chromatography biology Chemistry Plant Extracts Water Catechin Permeation biology.organism_classification Bioavailability Computational biology and bioinformatics Plant Leaves medicine.anatomical_structure Polyphenol Medicine Thermodynamics Emulsions Moisturizer Biotechnology |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Nanoemulsion is a delivery system used to enhance bioavailability of plant-based compounds across the stratum corneum. Elaeis guineensis leaves are rich source of polyphenolic antioxidants, viz. gallic acid and catechin. The optimal E. guineensis leaves extract water-in-oil nanoemulsion was stable against coalescence, but it was under significant influence of Ostwald ripening over 90 days at 25 °C. The in-vitro permeability revealed a controlled and sustained release of the total phenolic compounds (TPC) of EgLE with a cumulative amount of 1935.0 ± 45.7 µgcm−2 after 8 h. The steady-state flux and permeation coefficient values were 241.9 ± 5.7 µgcm−2 h−1 and 1.15 ± 0.03 cm.h−1, respectively. The kinetic release mechanism for TPC of EgLE was best described by the Korsmeyer–Peppas model due to the highest linearity of R2 = 0.9961, indicating super case II transport mechanism. The in-silico molecular modelling predicted that the aquaporin-3 protein in the stratum corneum bonded preferably to catechin over gallic acid through hydrogen bonds due to the lowest binding energies of − 57.514 kcal/mol and − 8.553 kcal/mol, respectively. Thus, the in-silico study further verified that catechin could improve skin hydration. Therefore, the optimal nanoemulsion could be used topically as moisturizer to enhance skin hydration based on the in-silico prediction. |
| Databáze: | OpenAIRE |
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